The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma

The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma

Abstract Background The survival and proliferation of multiple myeloma (MM) cells in the bone marrow (BM) critically depend on interaction with stromal cells expressing the chemokine CXCL12. CXCL12 regulates the homing to the BM niche by mediating the transendothelial migration and adhesion/retentio...

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Bibliographic Details
Main Authors:	Zemin Ren, Hildo Lantermans, Annemieke Kuil, Willem Kraan, Fernando Arenzana-Seisdedos, Marie José Kersten, Marcel Spaargaren, Steven T. Pals
Format:	Article
Language:	English
Published:	BMC 2021-01-01
Series:	Journal of Hematology & Oncology
Subjects:	Multiple myeloma CXCL12 Heparan sulfate proteoglycans Bone marrow stromal cells Adhesion Drug resistance
Online Access:	https://doi.org/10.1186/s13045-021-01031-3

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