Association between redox imbalance, pterin metabolism markers, and early extrapyramidal side effects of antipsychotics in schizophrenia: pilot study
Antipsychotics (AP) administration in schizophrenia patients is associated with several side effects (SE), in particular, with extrapyramidal (EP). Data suggests that oxidative damage to dopaminergic neurons in the EP system may be related to tardive dyskinesia and Parkinson's disease (PD) deve...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2022-04-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
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| Online Access: | https://nnp.ima-press.net/nnp/article/view/1780 |
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| author | T. V. Zhilyaeva D. S. Shvachkina A. S. Piatoikina E. S. Zhukova O. V. Kostina T. G. Shcherbatyuk G. E. Mazo |
| author_facet | T. V. Zhilyaeva D. S. Shvachkina A. S. Piatoikina E. S. Zhukova O. V. Kostina T. G. Shcherbatyuk G. E. Mazo |
| author_sort | T. V. Zhilyaeva |
| collection | DOAJ |
| description | Antipsychotics (AP) administration in schizophrenia patients is associated with several side effects (SE), in particular, with extrapyramidal (EP). Data suggests that oxidative damage to dopaminergic neurons in the EP system may be related to tardive dyskinesia and Parkinson's disease (PD) development, although data on the role of oxidative stress in the development of early EPSE of AP is lacking. Another poorly studied hypothesis of the EP-symptoms pathogenesis considers disorders of folate (pterin) metabolism.Objective: to evaluate the relationship between redox imbalance and pterin metabolism with the severity of early EPSE caused by AP used in the schizophrenia treatment.Patients and methods. The study included 50 patients with the first episode of schizophrenia. EP symptoms were evaluated using the UKU Side-Effect Rating Scale (“UKU-SERS-Clin” version). The levels of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), aldehyde-2,4-dinitrophenylhydrazone, ketone-2,4-dinitrophenylhydrazone were assessed in blood plasma; levels of BH4, folate, cobalamin (vitamin B12), and homocysteine – in blood serum; superoxide dismutase (SOD) and catalase activity – in erythrocytes.Results and discussion. EPSE severity was inversely proportional inversely proportional to the GSH level and directly proportional to the SOD activity. EPSE severity was also associated with AP selectivity, but not with their dosages. However, AP selectivity was not associated with studied biochemical parameters. MDA level in patients prescribed with amantadine was lower than in other participants.Conclusion. Early AP-induced EPSE were associated with redox imbalance, which indicates the necessity for further research aiming at prevention of secondary neurodegenerative diseases in patients with schizophrenia receiving AP. |
| first_indexed | 2024-04-10T02:00:56Z |
| format | Article |
| id | doaj.art-6fe6652c184148749720eff40415dc7e |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2024-04-10T02:00:56Z |
| publishDate | 2022-04-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-6fe6652c184148749720eff40415dc7e2023-03-13T08:42:22ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422022-04-01142182510.14412/2074-2711-2022-2-18-251246Association between redox imbalance, pterin metabolism markers, and early extrapyramidal side effects of antipsychotics in schizophrenia: pilot studyT. V. Zhilyaeva0D. S. Shvachkina1A. S. Piatoikina2E. S. Zhukova3O. V. Kostina4T. G. Shcherbatyuk5G. E. Mazo6Privolzhsky Research Medical University, Ministry of Health of Russia; V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of RussiaPrivolzhsky Research Medical University, Ministry of Health of RussiaNizhny Novgorod City Clinical Psychiatric Hospital №1Nizhny Novgorod Research Institute for Hygiene and Occupational Pathology, RospotrebnadzorPrivolzhsky Research Medical University, Ministry of Health of RussiaNizhny Novgorod Research Institute for Hygiene and Occupational Pathology, Rospotrebnadzor; Pushchino State Institute of Natural SciencePushchino State Institute of Natural ScienceAntipsychotics (AP) administration in schizophrenia patients is associated with several side effects (SE), in particular, with extrapyramidal (EP). Data suggests that oxidative damage to dopaminergic neurons in the EP system may be related to tardive dyskinesia and Parkinson's disease (PD) development, although data on the role of oxidative stress in the development of early EPSE of AP is lacking. Another poorly studied hypothesis of the EP-symptoms pathogenesis considers disorders of folate (pterin) metabolism.Objective: to evaluate the relationship between redox imbalance and pterin metabolism with the severity of early EPSE caused by AP used in the schizophrenia treatment.Patients and methods. The study included 50 patients with the first episode of schizophrenia. EP symptoms were evaluated using the UKU Side-Effect Rating Scale (“UKU-SERS-Clin” version). The levels of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), aldehyde-2,4-dinitrophenylhydrazone, ketone-2,4-dinitrophenylhydrazone were assessed in blood plasma; levels of BH4, folate, cobalamin (vitamin B12), and homocysteine – in blood serum; superoxide dismutase (SOD) and catalase activity – in erythrocytes.Results and discussion. EPSE severity was inversely proportional inversely proportional to the GSH level and directly proportional to the SOD activity. EPSE severity was also associated with AP selectivity, but not with their dosages. However, AP selectivity was not associated with studied biochemical parameters. MDA level in patients prescribed with amantadine was lower than in other participants.Conclusion. Early AP-induced EPSE were associated with redox imbalance, which indicates the necessity for further research aiming at prevention of secondary neurodegenerative diseases in patients with schizophrenia receiving AP.https://nnp.ima-press.net/nnp/article/view/1780antipsychoticsextrapyramidal side effectsoxidative stresspterin metabolism |
| spellingShingle | T. V. Zhilyaeva D. S. Shvachkina A. S. Piatoikina E. S. Zhukova O. V. Kostina T. G. Shcherbatyuk G. E. Mazo Association between redox imbalance, pterin metabolism markers, and early extrapyramidal side effects of antipsychotics in schizophrenia: pilot study Неврология, нейропсихиатрия, психосоматика antipsychotics extrapyramidal side effects oxidative stress pterin metabolism |
| title | Association between redox imbalance, pterin metabolism markers, and early extrapyramidal side effects of antipsychotics in schizophrenia: pilot study |
| title_full | Association between redox imbalance, pterin metabolism markers, and early extrapyramidal side effects of antipsychotics in schizophrenia: pilot study |
| title_fullStr | Association between redox imbalance, pterin metabolism markers, and early extrapyramidal side effects of antipsychotics in schizophrenia: pilot study |
| title_full_unstemmed | Association between redox imbalance, pterin metabolism markers, and early extrapyramidal side effects of antipsychotics in schizophrenia: pilot study |
| title_short | Association between redox imbalance, pterin metabolism markers, and early extrapyramidal side effects of antipsychotics in schizophrenia: pilot study |
| title_sort | association between redox imbalance pterin metabolism markers and early extrapyramidal side effects of antipsychotics in schizophrenia pilot study |
| topic | antipsychotics extrapyramidal side effects oxidative stress pterin metabolism |
| url | https://nnp.ima-press.net/nnp/article/view/1780 |
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