A germline JAK2 exon12 mutation and a late somatic CALR mutation in a patient with essential thrombocythemia

A germline JAK2 exon12 mutation and a late somatic CALR mutation in a patient with essential thrombocythemia

BackgroundIt has been discovered that Janus kinase 2 (JAK2) exon12 mutations lead to the polycythemia vera (PV) phenotype, while somatic mutations of calreticulin (CALR) are associated with essential thrombocythemia (ET) or primary myelofibrosis. In this article, we report a case of ET with coexiste...

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Bibliographic Details
Main Authors: Zhuanghui Hao, Juan Li, Feng Gao, Weixiao Ren, Xiaomei Lu, Jinyi Feng, Chen Zhang, Sicheng Bian, Juan Xie, Ming Luo, Jianmei Chang, Wanfang Yang, Ruixia Hou, Daniel Muteb Muyey, Jing Xu, Jiangxia Cui, Xiuhua Chen, Hongwei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Oncology
Subjects:
essential thrombocythemia
JAK2 exon12 mutation
CALR type1 mutation
distinct phenotype
myeloproliferative neoplasms
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1265022/full

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