Adverse reactions of Methylphenidate in children with attention deficit-hyperactivity disorder: Report from a referral center
Objective: The aim of the current study was to determine various aspects of methylphenidate adverse reactions in children with attention deficit-hyperactivity disorder (ADHD) in Iran. Methods: During the 6 months period, all children under methylphenidate treatment alone or along with other agents...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
|
| Series: | Journal of Research in Pharmacy Practice |
| Subjects: | |
| Online Access: | http://www.jrpp.net/article.asp?issn=2319-9644;year=2014;volume=3;issue=4;spage=130;epage=136;aulast=Khajehpiri |
| _version_ | 1819111440395534336 |
|---|---|
| author | Zahra Khajehpiri Javad Mahmoudi-Gharaei Toktam Faghihi Iman Karimzadeh Hossein Khalili Mostafa Mohammadi |
| author_facet | Zahra Khajehpiri Javad Mahmoudi-Gharaei Toktam Faghihi Iman Karimzadeh Hossein Khalili Mostafa Mohammadi |
| author_sort | Zahra Khajehpiri |
| collection | DOAJ |
| description | Objective: The aim of the current study was to determine various aspects of methylphenidate adverse reactions in children with attention deficit-hyperactivity disorder (ADHD) in Iran.
Methods: During the 6 months period, all children under methylphenidate treatment alone or along with other agents attending a university-affiliated psychology clinic were screened regarding all subjective and objective adverse drug reactions (ADRs) of methylphenidate. Causality and seriousness of detected ADRs were assessed by relevant World Health Organization definitions. The Schumock and Thornton questionnaire was used to determine preventability of ADRs.
Findings: Seventy-one patients including 25 girls and 46 boys with ADHD under methylphenidate treatment were enrolled within the study period. All (100%) ADHD children under methylphenidate treatment developed at least one ADR. Anorexia (74.3%), irritability (57.1%), and insomnia (47.2%) were the most frequent methylphenidate-related adverse reactions. Except for one, all other detected ADRs were determined to be mild. In addition, no ADR was considered to be preventable and serious.
Conclusion: Our data suggested that although methylphenidate related adverse reactions were common in children with ADHD, but they were mainly mild and nonserious. |
| first_indexed | 2024-12-22T03:57:39Z |
| format | Article |
| id | doaj.art-6fe7f75f03f740d6934f77c6bced272f |
| institution | Directory Open Access Journal |
| issn | 2319-9644 2279-042X |
| language | English |
| last_indexed | 2024-12-22T03:57:39Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Pharmacy Practice |
| spelling | doaj.art-6fe7f75f03f740d6934f77c6bced272f2022-12-21T18:39:50ZengWolters Kluwer Medknow PublicationsJournal of Research in Pharmacy Practice2319-96442279-042X2014-01-013413013610.4103/2279-042X.145389Adverse reactions of Methylphenidate in children with attention deficit-hyperactivity disorder: Report from a referral centerZahra KhajehpiriJavad Mahmoudi-GharaeiToktam FaghihiIman KarimzadehHossein KhaliliMostafa MohammadiObjective: The aim of the current study was to determine various aspects of methylphenidate adverse reactions in children with attention deficit-hyperactivity disorder (ADHD) in Iran. Methods: During the 6 months period, all children under methylphenidate treatment alone or along with other agents attending a university-affiliated psychology clinic were screened regarding all subjective and objective adverse drug reactions (ADRs) of methylphenidate. Causality and seriousness of detected ADRs were assessed by relevant World Health Organization definitions. The Schumock and Thornton questionnaire was used to determine preventability of ADRs. Findings: Seventy-one patients including 25 girls and 46 boys with ADHD under methylphenidate treatment were enrolled within the study period. All (100%) ADHD children under methylphenidate treatment developed at least one ADR. Anorexia (74.3%), irritability (57.1%), and insomnia (47.2%) were the most frequent methylphenidate-related adverse reactions. Except for one, all other detected ADRs were determined to be mild. In addition, no ADR was considered to be preventable and serious. Conclusion: Our data suggested that although methylphenidate related adverse reactions were common in children with ADHD, but they were mainly mild and nonserious.http://www.jrpp.net/article.asp?issn=2319-9644;year=2014;volume=3;issue=4;spage=130;epage=136;aulast=KhajehpiriAdverse drug reactions; attention deficit-hyperactivity disorder; Methylphenidate |
| spellingShingle | Zahra Khajehpiri Javad Mahmoudi-Gharaei Toktam Faghihi Iman Karimzadeh Hossein Khalili Mostafa Mohammadi Adverse reactions of Methylphenidate in children with attention deficit-hyperactivity disorder: Report from a referral center Journal of Research in Pharmacy Practice Adverse drug reactions; attention deficit-hyperactivity disorder; Methylphenidate |
| title | Adverse reactions of Methylphenidate in children with attention deficit-hyperactivity disorder: Report from a referral center |
| title_full | Adverse reactions of Methylphenidate in children with attention deficit-hyperactivity disorder: Report from a referral center |
| title_fullStr | Adverse reactions of Methylphenidate in children with attention deficit-hyperactivity disorder: Report from a referral center |
| title_full_unstemmed | Adverse reactions of Methylphenidate in children with attention deficit-hyperactivity disorder: Report from a referral center |
| title_short | Adverse reactions of Methylphenidate in children with attention deficit-hyperactivity disorder: Report from a referral center |
| title_sort | adverse reactions of methylphenidate in children with attention deficit hyperactivity disorder report from a referral center |
| topic | Adverse drug reactions; attention deficit-hyperactivity disorder; Methylphenidate |
| url | http://www.jrpp.net/article.asp?issn=2319-9644;year=2014;volume=3;issue=4;spage=130;epage=136;aulast=Khajehpiri |
| work_keys_str_mv | AT zahrakhajehpiri adversereactionsofmethylphenidateinchildrenwithattentiondeficithyperactivitydisorderreportfromareferralcenter AT javadmahmoudigharaei adversereactionsofmethylphenidateinchildrenwithattentiondeficithyperactivitydisorderreportfromareferralcenter AT toktamfaghihi adversereactionsofmethylphenidateinchildrenwithattentiondeficithyperactivitydisorderreportfromareferralcenter AT imankarimzadeh adversereactionsofmethylphenidateinchildrenwithattentiondeficithyperactivitydisorderreportfromareferralcenter AT hosseinkhalili adversereactionsofmethylphenidateinchildrenwithattentiondeficithyperactivitydisorderreportfromareferralcenter AT mostafamohammadi adversereactionsofmethylphenidateinchildrenwithattentiondeficithyperactivitydisorderreportfromareferralcenter |