A Survey of Growth Hormone Stimulation Test Efficacy for Workup of Short Stature in a Referral Laboratory
Objective: To assess growth hormone (GH) stimulation test efficacy in short stature workup for establishing GH deficiency. Study Design: Cross-sectional survey. Place and Duration of Study: Diagnostic Endocrine Section, Department of Chemical Pathology & Endocrinology, Armed Forces Insti...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Army Medical College Rawalpindi
2023-04-01
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Series: | Pakistan Armed Forces Medical Journal |
Subjects: | |
Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/7906 |
Summary: | Objective: To assess growth hormone (GH) stimulation test efficacy in short stature workup for establishing GH deficiency.
Study Design: Cross-sectional survey.
Place and Duration of Study: Diagnostic Endocrine Section, Department of Chemical Pathology & Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, from Aug 2020 to Jan 2021.
Methodology: The study was conducted on 129 individuals aged 2-16 years. History, axiological data and biochemical parameters were assessed to establish GH deficiency for short stature workup.
Results: Out of 129 individuals, 76(59%) boys and 53(41%) girls reported GH stimulation tests. 81(62.3%) children were in <3rd percentile, 29(22.3%) in <5th percentile, 9(6.9%) in <10th percentile and 5(3.8%) in <25th percentile. Among the group with bone age difference >2 years, 34(82.9%) fell in <3rd percentile. GH Stimulation test post-Levo Dopa was performed in 102(78.46%) patients. 49(37.4%) patients responded inadequately to the GH stimulation test. The adequate response to the GH Stimulation test improved as the percentile declined from the 50th to the 3rd percentile.
Conclusion: GH stimulation test results can only partially rely upon though their importance remains in combination with other short-stature workup parameters for ruling out growth hormone deficiency.
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ISSN: | 0030-9648 2411-8842 |