A Survey of Growth Hormone Stimulation Test Efficacy for Workup of Short Stature in a Referral Laboratory
Objective: To assess growth hormone (GH) stimulation test efficacy in short stature workup for establishing GH deficiency. Study Design: Cross-sectional survey. Place and Duration of Study: Diagnostic Endocrine Section, Department of Chemical Pathology & Endocrinology, Armed Forces Insti...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2023-04-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/7906 |
| _version_ | 1797826697977921536 |
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| author | Muhammad Usman Munir Muhammad Aamir Zujaja Hina Haroon Sobia Irum Kirmani Afshan Yasir Hunain Habib |
| author_facet | Muhammad Usman Munir Muhammad Aamir Zujaja Hina Haroon Sobia Irum Kirmani Afshan Yasir Hunain Habib |
| author_sort | Muhammad Usman Munir |
| collection | DOAJ |
| description |
Objective: To assess growth hormone (GH) stimulation test efficacy in short stature workup for establishing GH deficiency.
Study Design: Cross-sectional survey.
Place and Duration of Study: Diagnostic Endocrine Section, Department of Chemical Pathology & Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, from Aug 2020 to Jan 2021.
Methodology: The study was conducted on 129 individuals aged 2-16 years. History, axiological data and biochemical parameters were assessed to establish GH deficiency for short stature workup.
Results: Out of 129 individuals, 76(59%) boys and 53(41%) girls reported GH stimulation tests. 81(62.3%) children were in <3rd percentile, 29(22.3%) in <5th percentile, 9(6.9%) in <10th percentile and 5(3.8%) in <25th percentile. Among the group with bone age difference >2 years, 34(82.9%) fell in <3rd percentile. GH Stimulation test post-Levo Dopa was performed in 102(78.46%) patients. 49(37.4%) patients responded inadequately to the GH stimulation test. The adequate response to the GH Stimulation test improved as the percentile declined from the 50th to the 3rd percentile.
Conclusion: GH stimulation test results can only partially rely upon though their importance remains in combination with other short-stature workup parameters for ruling out growth hormone deficiency.
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| first_indexed | 2024-04-09T12:36:29Z |
| format | Article |
| id | doaj.art-6fe9ef3d9f0a4483b495518e1617c8a1 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-04-09T12:36:29Z |
| publishDate | 2023-04-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-6fe9ef3d9f0a4483b495518e1617c8a12023-05-15T09:44:28ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422023-04-0173210.51253/pafmj.v73i2.7906A Survey of Growth Hormone Stimulation Test Efficacy for Workup of Short Stature in a Referral LaboratoryMuhammad Usman Munir0Muhammad Aamir1Zujaja Hina Haroon2Sobia Irum Kirmani3Afshan Yasir4Hunain Habib5Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan Objective: To assess growth hormone (GH) stimulation test efficacy in short stature workup for establishing GH deficiency. Study Design: Cross-sectional survey. Place and Duration of Study: Diagnostic Endocrine Section, Department of Chemical Pathology & Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, from Aug 2020 to Jan 2021. Methodology: The study was conducted on 129 individuals aged 2-16 years. History, axiological data and biochemical parameters were assessed to establish GH deficiency for short stature workup. Results: Out of 129 individuals, 76(59%) boys and 53(41%) girls reported GH stimulation tests. 81(62.3%) children were in <3rd percentile, 29(22.3%) in <5th percentile, 9(6.9%) in <10th percentile and 5(3.8%) in <25th percentile. Among the group with bone age difference >2 years, 34(82.9%) fell in <3rd percentile. GH Stimulation test post-Levo Dopa was performed in 102(78.46%) patients. 49(37.4%) patients responded inadequately to the GH stimulation test. The adequate response to the GH Stimulation test improved as the percentile declined from the 50th to the 3rd percentile. Conclusion: GH stimulation test results can only partially rely upon though their importance remains in combination with other short-stature workup parameters for ruling out growth hormone deficiency. https://www.pafmj.org/index.php/PAFMJ/article/view/7906Growth hormone stimulation testsShort statureHeight percentile |
| spellingShingle | Muhammad Usman Munir Muhammad Aamir Zujaja Hina Haroon Sobia Irum Kirmani Afshan Yasir Hunain Habib A Survey of Growth Hormone Stimulation Test Efficacy for Workup of Short Stature in a Referral Laboratory Pakistan Armed Forces Medical Journal Growth hormone stimulation tests Short stature Height percentile |
| title | A Survey of Growth Hormone Stimulation Test Efficacy for Workup of Short Stature in a Referral Laboratory |
| title_full | A Survey of Growth Hormone Stimulation Test Efficacy for Workup of Short Stature in a Referral Laboratory |
| title_fullStr | A Survey of Growth Hormone Stimulation Test Efficacy for Workup of Short Stature in a Referral Laboratory |
| title_full_unstemmed | A Survey of Growth Hormone Stimulation Test Efficacy for Workup of Short Stature in a Referral Laboratory |
| title_short | A Survey of Growth Hormone Stimulation Test Efficacy for Workup of Short Stature in a Referral Laboratory |
| title_sort | survey of growth hormone stimulation test efficacy for workup of short stature in a referral laboratory |
| topic | Growth hormone stimulation tests Short stature Height percentile |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/7906 |
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