Peripheral immune system in aging and Alzheimer’s disease
Abstract Alzheimer’s disease (AD) represents an urgent public health mandate. AD is no longer considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a critical role played by neuroinflammation in the pathogeneses of AD and other neurodegenerative conditions. A c...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-10-01
|
| Series: | Molecular Neurodegeneration |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13024-018-0284-2 |
| _version_ | 1818178225170284544 |
|---|---|
| author | Wei Cao Hui Zheng |
| author_facet | Wei Cao Hui Zheng |
| author_sort | Wei Cao |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD) represents an urgent public health mandate. AD is no longer considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a critical role played by neuroinflammation in the pathogeneses of AD and other neurodegenerative conditions. A close functional connection between the immune system and central nervous system is increasingly recognized. In late-onset AD, aging represents the most significant risk factor. Here, from an immunological perspective, we summarize the prominent molecular and cellular changes in the periphery of aging individuals and AD patients. Moreover, we review the knowledge gained in the past several years that implicate specific arms of the peripheral immune system and other types of immune responses in modulating AD progression. Taken together, these findings collectively emphasize a dynamic role of a concert of brain-extrinsic, peripheral signals in the aging and degenerative processes in the CNS. We believe that a systematic view synthesizing the vast amounts of existing results will help guide the development of next-generation therapeutics and inform future directions of AD investigation. |
| first_indexed | 2024-12-11T20:44:35Z |
| format | Article |
| id | doaj.art-6feabae2e6aa49dc8febf0962ac0ddcc |
| institution | Directory Open Access Journal |
| issn | 1750-1326 |
| language | English |
| last_indexed | 2024-12-11T20:44:35Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj.art-6feabae2e6aa49dc8febf0962ac0ddcc2022-12-22T00:51:24ZengBMCMolecular Neurodegeneration1750-13262018-10-0113111710.1186/s13024-018-0284-2Peripheral immune system in aging and Alzheimer’s diseaseWei Cao0Hui Zheng1Department of Molecular and Human Genetics, Baylor College of Medicine, Huffington Center on AgingDepartment of Molecular and Human Genetics, Baylor College of Medicine, Huffington Center on AgingAbstract Alzheimer’s disease (AD) represents an urgent public health mandate. AD is no longer considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a critical role played by neuroinflammation in the pathogeneses of AD and other neurodegenerative conditions. A close functional connection between the immune system and central nervous system is increasingly recognized. In late-onset AD, aging represents the most significant risk factor. Here, from an immunological perspective, we summarize the prominent molecular and cellular changes in the periphery of aging individuals and AD patients. Moreover, we review the knowledge gained in the past several years that implicate specific arms of the peripheral immune system and other types of immune responses in modulating AD progression. Taken together, these findings collectively emphasize a dynamic role of a concert of brain-extrinsic, peripheral signals in the aging and degenerative processes in the CNS. We believe that a systematic view synthesizing the vast amounts of existing results will help guide the development of next-generation therapeutics and inform future directions of AD investigation.http://link.springer.com/article/10.1186/s13024-018-0284-2Alzheimer’s diseaseAgingSenescencePeripheral immune responseAdaptive immune responseHumoral immune response |
| spellingShingle | Wei Cao Hui Zheng Peripheral immune system in aging and Alzheimer’s disease Molecular Neurodegeneration Alzheimer’s disease Aging Senescence Peripheral immune response Adaptive immune response Humoral immune response |
| title | Peripheral immune system in aging and Alzheimer’s disease |
| title_full | Peripheral immune system in aging and Alzheimer’s disease |
| title_fullStr | Peripheral immune system in aging and Alzheimer’s disease |
| title_full_unstemmed | Peripheral immune system in aging and Alzheimer’s disease |
| title_short | Peripheral immune system in aging and Alzheimer’s disease |
| title_sort | peripheral immune system in aging and alzheimer s disease |
| topic | Alzheimer’s disease Aging Senescence Peripheral immune response Adaptive immune response Humoral immune response |
| url | http://link.springer.com/article/10.1186/s13024-018-0284-2 |
| work_keys_str_mv | AT weicao peripheralimmunesysteminagingandalzheimersdisease AT huizheng peripheralimmunesysteminagingandalzheimersdisease |