Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation
Protein binding to the non-coding regions of mRNAs is relatively well characterized and its functionality has been described in many examples. New results obtained by high-throughput methods indicate that binding to the coding sequence (CDS) by RNA-binding proteins is also quite common, but the func...
| मुख्य लेखकों: | , |
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| स्वरूप: | लेख |
| भाषा: | English |
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MDPI AG
2021-10-01
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| श्रृंखला: | Cells |
| विषय: | |
| ऑनलाइन पहुंच: | https://www.mdpi.com/2073-4409/10/11/2910 |
| _version_ | 1827677020804349952 |
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| author | Ewa A. Grzybowska Maciej Wakula |
| author_facet | Ewa A. Grzybowska Maciej Wakula |
| author_sort | Ewa A. Grzybowska |
| collection | DOAJ |
| description | Protein binding to the non-coding regions of mRNAs is relatively well characterized and its functionality has been described in many examples. New results obtained by high-throughput methods indicate that binding to the coding sequence (CDS) by RNA-binding proteins is also quite common, but the functions thereof are more obscure. As described in this review, CDS binding has a role in the regulation of mRNA stability, but it has also a more intriguing role in the regulation of translational efficiency. Global approaches, which suggest the significance of CDS binding along with specific examples of CDS-binding RBPs and their modes of action, are outlined here, pointing to the existence of a relatively less-known regulatory network controlling mRNA stability and translation on yet another level. |
| first_indexed | 2024-03-10T05:37:22Z |
| format | Article |
| id | doaj.art-6feae23f8c894cd4880f33a68e10b65e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:37:22Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6feae23f8c894cd4880f33a68e10b65e2023-11-22T22:48:33ZengMDPI AGCells2073-44092021-10-011011291010.3390/cells10112910Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of TranslationEwa A. Grzybowska0Maciej Wakula1Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, PolandMolecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, PolandProtein binding to the non-coding regions of mRNAs is relatively well characterized and its functionality has been described in many examples. New results obtained by high-throughput methods indicate that binding to the coding sequence (CDS) by RNA-binding proteins is also quite common, but the functions thereof are more obscure. As described in this review, CDS binding has a role in the regulation of mRNA stability, but it has also a more intriguing role in the regulation of translational efficiency. Global approaches, which suggest the significance of CDS binding along with specific examples of CDS-binding RBPs and their modes of action, are outlined here, pointing to the existence of a relatively less-known regulatory network controlling mRNA stability and translation on yet another level.https://www.mdpi.com/2073-4409/10/11/2910RNA-binding proteinscoding sequencemammalian post-transcriptional gene expression |
| spellingShingle | Ewa A. Grzybowska Maciej Wakula Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation Cells RNA-binding proteins coding sequence mammalian post-transcriptional gene expression |
| title | Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation |
| title_full | Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation |
| title_fullStr | Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation |
| title_full_unstemmed | Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation |
| title_short | Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation |
| title_sort | protein binding to cis motifs in mrnas coding sequence is common and regulates transcript stability and the rate of translation |
| topic | RNA-binding proteins coding sequence mammalian post-transcriptional gene expression |
| url | https://www.mdpi.com/2073-4409/10/11/2910 |
| work_keys_str_mv | AT ewaagrzybowska proteinbindingtocismotifsinmrnascodingsequenceiscommonandregulatestranscriptstabilityandtherateoftranslation AT maciejwakula proteinbindingtocismotifsinmrnascodingsequenceiscommonandregulatestranscriptstabilityandtherateoftranslation |