The effect of fasting on the diurnal rhythm of rat ACHT and corticosterone secretion
A tight association of feeding, metabolism, and function of the hypothalamo-pituitary-adrenocortical (HPA) axis is well known. Studies of HPA axis responsivity to various diets and food restriction show that not only fasting but also the cyclic circadian input importantly determine these responses....
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2008-01-01
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| Series: | Archives of Biological Sciences |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2008/0354-46640804541D.pdf |
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| author | Đorđević Jelena Jasnić N. Vujović P. Đurašević S. Đorđević Iva Cvijić Gordana |
| author_facet | Đorđević Jelena Jasnić N. Vujović P. Đurašević S. Đorđević Iva Cvijić Gordana |
| author_sort | Đorđević Jelena |
| collection | DOAJ |
| description | A tight association of feeding, metabolism, and function of the hypothalamo-pituitary-adrenocortical (HPA) axis is well known. Studies of HPA axis responsivity to various diets and food restriction show that not only fasting but also the cyclic circadian input importantly determine these responses. We therefore studied the response of the rat HPA system to different fasting periods (12, 18, 24, 36, and 48 h), all imposed at 6 PM, by measuring blood ACTH and corticosterone concentration. The corresponding metabolic parameters, e.g., blood glucose and free fatty acid (FFA) levels, were also assessed. The obtained results show that fasting altered the normal diurnal rhythm in levels of blood ACTH and FFA, but not corticosterone and glucose. All applied fasting periods increased HPA system activity in comparison with ad libitum fed rats. However, the most pronounced elevation in the blood ACTH concentration was observed after 18 h and 36 h of fasting, while the CORT increment was the highest 48 h after food restriction began. As expected, the blood glucose concentration decreased under the influence of all fasting periods, being the lowest after 12 h of overnight fasting. In contrast to that, fasted rats exhibited a normal level of serum FFA early in the morning, an elevated level thereafter, and the peak level 48 h after the onset of starvation. |
| first_indexed | 2024-12-17T10:16:18Z |
| format | Article |
| id | doaj.art-6fed3cd7e6a34a38aef13b241ab55e70 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 |
| language | English |
| last_indexed | 2024-12-17T10:16:18Z |
| publishDate | 2008-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-6fed3cd7e6a34a38aef13b241ab55e702022-12-21T21:52:54ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642008-01-0160454154610.2298/ABS0804541DThe effect of fasting on the diurnal rhythm of rat ACHT and corticosterone secretionĐorđević JelenaJasnić N.Vujović P.Đurašević S.Đorđević IvaCvijić GordanaA tight association of feeding, metabolism, and function of the hypothalamo-pituitary-adrenocortical (HPA) axis is well known. Studies of HPA axis responsivity to various diets and food restriction show that not only fasting but also the cyclic circadian input importantly determine these responses. We therefore studied the response of the rat HPA system to different fasting periods (12, 18, 24, 36, and 48 h), all imposed at 6 PM, by measuring blood ACTH and corticosterone concentration. The corresponding metabolic parameters, e.g., blood glucose and free fatty acid (FFA) levels, were also assessed. The obtained results show that fasting altered the normal diurnal rhythm in levels of blood ACTH and FFA, but not corticosterone and glucose. All applied fasting periods increased HPA system activity in comparison with ad libitum fed rats. However, the most pronounced elevation in the blood ACTH concentration was observed after 18 h and 36 h of fasting, while the CORT increment was the highest 48 h after food restriction began. As expected, the blood glucose concentration decreased under the influence of all fasting periods, being the lowest after 12 h of overnight fasting. In contrast to that, fasted rats exhibited a normal level of serum FFA early in the morning, an elevated level thereafter, and the peak level 48 h after the onset of starvation.http://www.doiserbia.nb.rs/img/doi/0354-4664/2008/0354-46640804541D.pdfACTHcorticosteronefastingglucoseFFAhypothalamo-pituitary-adrenal system |
| spellingShingle | Đorđević Jelena Jasnić N. Vujović P. Đurašević S. Đorđević Iva Cvijić Gordana The effect of fasting on the diurnal rhythm of rat ACHT and corticosterone secretion Archives of Biological Sciences ACTH corticosterone fasting glucose FFA hypothalamo-pituitary-adrenal system |
| title | The effect of fasting on the diurnal rhythm of rat ACHT and corticosterone secretion |
| title_full | The effect of fasting on the diurnal rhythm of rat ACHT and corticosterone secretion |
| title_fullStr | The effect of fasting on the diurnal rhythm of rat ACHT and corticosterone secretion |
| title_full_unstemmed | The effect of fasting on the diurnal rhythm of rat ACHT and corticosterone secretion |
| title_short | The effect of fasting on the diurnal rhythm of rat ACHT and corticosterone secretion |
| title_sort | effect of fasting on the diurnal rhythm of rat acht and corticosterone secretion |
| topic | ACTH corticosterone fasting glucose FFA hypothalamo-pituitary-adrenal system |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2008/0354-46640804541D.pdf |
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