Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions

Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions

2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are nota...

Full description

Bibliographic Details
Main Authors: Ching-Fa Yao, Veerababurao Kavala, Chun-Chao Wang, Chun-Wei Kuo
Format: Article
Language:English
Published: MDPI AG 2008-09-01
Series:Molecules
Subjects:
Benzodiazepines
2
4
6-trichloro-1
3
5-triazine
enolizable ketones
o-phenylenediamines
Online Access:http://www.mdpi.com/1420-3049/13/9/2313/
Description
Summary:2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.
ISSN:1420-3049

Similar Items