A randomized single-dose, two-period crossover bioequivalence study of two fixed-dose Paracetamol/Orphenadrine combination preparations in healthy volunteers under fasted condition

A randomized single-dose, two-period crossover bioequivalence study of two fixed-dose Paracetamol/Orphenadrine combination preparations in healthy volunteers under fasted condition

Abstract Background Paracetamol/Orphenadrine is a fixed dose combination containing 35 mg orphenadrine and 450 mg paracetamol. It has analgesic and muscle relaxant properties and is widely available as generics. This study is conducted to investigate the relative bioavailability and bioequivalence b...

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Bibliographic Details
Main Authors: Kit Yee Cheah, Kar Yee Mah, Lai Hui Pang, Shi Min Ng, Jia Woei Wong, Siew Siew Tan, Hong Zhe Tan, Kah Hay Yuen
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Pharmacology and Toxicology
Subjects:
Bioequivalence
Fasted
Orphenadrine
Paracetamol
Online Access:http://link.springer.com/article/10.1186/s40360-020-00416-3

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