Evaluating genomic signatures of aging in brain tissue as it relates to Alzheimer’s disease
Abstract Telomere length (TL) attrition, epigenetic age acceleration, and mitochondrial DNA copy number (mtDNAcn) decline are established hallmarks of aging. Each has been individually associated with Alzheimer’s dementia, cognitive function, and pathologic Alzheimer’s disease (AD). Epigenetic age a...
Main Authors: | Megan T. Lynch, Margaret A. Taub, Jose M. Farfel, Jingyun Yang, Peter Abadir, Philip L. De Jager, Francine Grodstein, David A. Bennett, Rasika A. Mathias |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-09-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-41400-1 |
Similar Items
-
Exploring cortical proteins underlying the relation of neuroticism to cognitive resilience
by: Francine Grodstein, et al.
Published: (2022-01-01) -
Brain chains as topological signatures for Alzheimer’s disease
by: Goodbrake, C, et al.
Published: (2024) -
Aberrant angiogenesis in brain tissue in experimental Alzheimer’s disease
by: Ya. V. Gorina, et al.
Published: (2021-01-01) -
Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults
by: Lolita S. Nidadavolu, et al.
Published: (2023-05-01) -
The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms
by: Daniel Felsky, et al.
Published: (2023-01-01)