Transcriptomic Profiling of DNA Damage Response in Patient-Derived Glioblastoma Cells before and after Radiation and Temozolomide Treatment

Transcriptomic Profiling of DNA Damage Response in Patient-Derived Glioblastoma Cells before and after Radiation and Temozolomide Treatment

Glioblastoma is a highly aggressive, invasive and treatment-resistant tumour. The DNA damage response (DDR) provides tumour cells with enhanced ability to activate cell cycle arrest and repair treatment-induced DNA damage. We studied the expression of DDR, its relationship with standard treatment re...

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Bibliographic Details
Main Authors: Mathew Lozinski, Nikola A. Bowden, Moira C. Graves, Michael Fay, Bryan W. Day, Brett W. Stringer, Paul A. Tooney
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
glioblastoma
DNA damage response
treatment resistance
temozolomide
radiation
Online Access:https://www.mdpi.com/2073-4409/11/7/1215

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