Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury

Background α Carboxyl terminus 1 (αCT1) is a 25–amino acid therapeutic peptide incorporating the zonula occludens‐1 (ZO‐1)–binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on chronic wounds. In mice, we reported that αCT1 reduced arrhythmias after cardiac injury, ac...

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Bibliographic Details
Main Authors: Jingbo Jiang, Daniel Hoagland, Joseph A. Palatinus, Huamei He, Jegan Iyyathurai, L. Jane Jourdan, Geert Bultynck, Zhen Wang, Zhiwei Zhang, Kevin Schey, Steven Poelzing, Francis X. McGowan, Robert G. Gourdie
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardioprotection
connexin 43
ischemia‐reperfusion injury
S368 phosphorylation
zonula occludens‐1
α carboxyl terminus 1
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.012385

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