Genome-Wide Association Study of Tacrolimus Pharmacokinetics Identifies Novel Single Nucleotide Polymorphisms in the Convalescence and Stabilization Periods of Post-transplant Liver Function

Genome-Wide Association Study of Tacrolimus Pharmacokinetics Identifies Novel Single Nucleotide Polymorphisms in the Convalescence and Stabilization Periods of Post-transplant Liver Function

After liver transplantation, the liver function of a patient is gradually restored over a period of time that can be divided into a convalescence period (CP) and a stabilizing period (SP). The plasma concentration of tacrolimus, an immunosuppressant commonly used to prevent organ rejection, varies a...

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Bibliographic Details
Main Authors: Yuan Liu, Chengdong Zhang, Lei Li, Baochi Ou, Liyun Yuan, Tao Zhang, Junwei Fan, Zhihai Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Genetics
Subjects:
GWAS
CYP3A5
exome
tacrolimus
FAM26F
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00528/full

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