A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling
Bile acids are important physiological agents required for the absorption, distribution, metabolism, and excretion of nutrients. In addition, bile acids act as sensors of intestinal contents, which are determined by the change in the spectrum of bile acids during microbial transformation, as well as...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/6/1983 |
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| author | Yulia Shulpekova Elena Shirokova Maria Zharkova Pyotr Tkachenko Igor Tikhonov Alexander Stepanov Alexandra Sinitsyna Alexander Izotov Tatyana Butkova Nadezhda Shulpekova Vladimir Nechaev Igor Damulin Alexey Okhlobystin Vladimir Ivashkin |
| author_facet | Yulia Shulpekova Elena Shirokova Maria Zharkova Pyotr Tkachenko Igor Tikhonov Alexander Stepanov Alexandra Sinitsyna Alexander Izotov Tatyana Butkova Nadezhda Shulpekova Vladimir Nechaev Igor Damulin Alexey Okhlobystin Vladimir Ivashkin |
| author_sort | Yulia Shulpekova |
| collection | DOAJ |
| description | Bile acids are important physiological agents required for the absorption, distribution, metabolism, and excretion of nutrients. In addition, bile acids act as sensors of intestinal contents, which are determined by the change in the spectrum of bile acids during microbial transformation, as well as by gradual intestinal absorption. Entering the liver through the portal vein, bile acids regulate the activity of nuclear receptors, modify metabolic processes and the rate of formation of new bile acids from cholesterol, and also, in all likelihood, can significantly affect the detoxification of xenobiotics. Bile acids not absorbed by the liver can interact with a variety of cellular recipes in extrahepatic tissues. This provides review information on the synthesis of bile acids in various parts of the digestive tract, its regulation, and the physiological role of bile acids. Moreover, the present study describes the involvement of bile acids in micelle formation, the mechanism of intestinal absorption, and the influence of the intestinal microbiota on this process. |
| first_indexed | 2024-03-09T13:09:39Z |
| format | Article |
| id | doaj.art-6ff466d09b784df8998625bc4e21cdf5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T13:09:39Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6ff466d09b784df8998625bc4e21cdf52023-11-30T21:44:10ZengMDPI AGMolecules1420-30492022-03-01276198310.3390/molecules27061983A Recent Ten-Year Perspective: Bile Acid Metabolism and SignalingYulia Shulpekova0Elena Shirokova1Maria Zharkova2Pyotr Tkachenko3Igor Tikhonov4Alexander Stepanov5Alexandra Sinitsyna6Alexander Izotov7Tatyana Butkova8Nadezhda Shulpekova9Vladimir Nechaev10Igor Damulin11Alexey Okhlobystin12Vladimir Ivashkin13Chair of Internal Diseases Propedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, RussiaChair of Internal Diseases Propedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, RussiaDepartment of Hepatology University Clinical Hospital No.2, Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, RussiaChair of Internal Diseases Propedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, RussiaChair of Internal Diseases Propedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, RussiaBiobanking Group, Branch of Institute of Biomedical Chemistry “Scientific and Education Center”, 109028 Moscow, RussiaBiobanking Group, Branch of Institute of Biomedical Chemistry “Scientific and Education Center”, 109028 Moscow, RussiaBiobanking Group, Branch of Institute of Biomedical Chemistry “Scientific and Education Center”, 109028 Moscow, RussiaBiobanking Group, Branch of Institute of Biomedical Chemistry “Scientific and Education Center”, 109028 Moscow, RussiaNational Medical Research Center of Endocrinology, 117292 Moscow, RussiaChair of Internal Diseases Propedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, RussiaBranch of the V. Serbsky National Medical Research Centre for Psychiatry and Narcology, 127994 Moscow, RussiaChair of Internal Diseases Propedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, RussiaChair of Internal Diseases Propedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, RussiaBile acids are important physiological agents required for the absorption, distribution, metabolism, and excretion of nutrients. In addition, bile acids act as sensors of intestinal contents, which are determined by the change in the spectrum of bile acids during microbial transformation, as well as by gradual intestinal absorption. Entering the liver through the portal vein, bile acids regulate the activity of nuclear receptors, modify metabolic processes and the rate of formation of new bile acids from cholesterol, and also, in all likelihood, can significantly affect the detoxification of xenobiotics. Bile acids not absorbed by the liver can interact with a variety of cellular recipes in extrahepatic tissues. This provides review information on the synthesis of bile acids in various parts of the digestive tract, its regulation, and the physiological role of bile acids. Moreover, the present study describes the involvement of bile acids in micelle formation, the mechanism of intestinal absorption, and the influence of the intestinal microbiota on this process.https://www.mdpi.com/1420-3049/27/6/1983bile acidsmetabolismregulation of bile acidsbile salts |
| spellingShingle | Yulia Shulpekova Elena Shirokova Maria Zharkova Pyotr Tkachenko Igor Tikhonov Alexander Stepanov Alexandra Sinitsyna Alexander Izotov Tatyana Butkova Nadezhda Shulpekova Vladimir Nechaev Igor Damulin Alexey Okhlobystin Vladimir Ivashkin A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling Molecules bile acids metabolism regulation of bile acids bile salts |
| title | A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling |
| title_full | A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling |
| title_fullStr | A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling |
| title_full_unstemmed | A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling |
| title_short | A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling |
| title_sort | recent ten year perspective bile acid metabolism and signaling |
| topic | bile acids metabolism regulation of bile acids bile salts |
| url | https://www.mdpi.com/1420-3049/27/6/1983 |
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