Effects of remote ischemic preconditioning on coronary blood flow and microcirculation
Abstract This study aimed to determine the effect of short-term remote ischemic preconditioning (RIPC) on coronary blood flow and microcirculation function using the quantitative flow ratio (QFR) and index of microcirculatory resistance (IMR). We randomly divided 129 patients undergoing coronary ang...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03419-0 |
| _version_ | 1827724853333983232 |
|---|---|
| author | Zhen-Zhou Zhao En Li Xue-Jie Li Quan Guo Qing-Bo Shi Mu-Wei Li |
| author_facet | Zhen-Zhou Zhao En Li Xue-Jie Li Quan Guo Qing-Bo Shi Mu-Wei Li |
| author_sort | Zhen-Zhou Zhao |
| collection | DOAJ |
| description | Abstract This study aimed to determine the effect of short-term remote ischemic preconditioning (RIPC) on coronary blood flow and microcirculation function using the quantitative flow ratio (QFR) and index of microcirculatory resistance (IMR). We randomly divided 129 patients undergoing coronary angiography (CAG) into RIPC and control groups. Following the first CAG, we randomly divided the patients further into the unilateral upper limb and lower limb groups for four cycles of ischemia/reperfusion circulation; subsequently, we performed the second CAG. During each CAG, contrast-flow QFR (cQFR), fixed-flow QFR (fQFR), and IMR (in patients with cardiac syndrome X) were calculated and compared. We measured 253 coronary arteries in 129 patients. Compared to the control group, the average cQFR of the RIPC group increased significantly after RIPC. Additionally, 23 patients with cardiac syndrome X (IMR > 30) were included in this study. Compared to the control group, IMR and the difference between cQFR and fQFR (cQFR-fQFR) both decreased significantly after receiving RIPC. The application of RIPC can increase coronary blood flow and improve coronary microcirculation function. |
| first_indexed | 2024-03-10T22:20:21Z |
| format | Article |
| id | doaj.art-6ff52dc724c54d3087c02285477aff8c |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-10T22:20:21Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-6ff52dc724c54d3087c02285477aff8c2023-11-19T12:18:46ZengBMCBMC Cardiovascular Disorders1471-22612023-08-012311810.1186/s12872-023-03419-0Effects of remote ischemic preconditioning on coronary blood flow and microcirculationZhen-Zhou Zhao0En Li1Xue-Jie Li2Quan Guo3Qing-Bo Shi4Mu-Wei Li5Heart Center of Henan Provincial People’s Hospital, Fuwai Central China Cardiovascular HospitalHeart Center of Henan Provincial People’s Hospital, Fuwai Central China Cardiovascular HospitalHeart Center of Henan Provincial People’s Hospital, Fuwai Central China Cardiovascular HospitalHeart Center of Henan Provincial People’s Hospital, Fuwai Central China Cardiovascular HospitalHeart Center of Henan Provincial People’s Hospital, Fuwai Central China Cardiovascular HospitalHeart Center of Henan Provincial People’s Hospital, Fuwai Central China Cardiovascular HospitalAbstract This study aimed to determine the effect of short-term remote ischemic preconditioning (RIPC) on coronary blood flow and microcirculation function using the quantitative flow ratio (QFR) and index of microcirculatory resistance (IMR). We randomly divided 129 patients undergoing coronary angiography (CAG) into RIPC and control groups. Following the first CAG, we randomly divided the patients further into the unilateral upper limb and lower limb groups for four cycles of ischemia/reperfusion circulation; subsequently, we performed the second CAG. During each CAG, contrast-flow QFR (cQFR), fixed-flow QFR (fQFR), and IMR (in patients with cardiac syndrome X) were calculated and compared. We measured 253 coronary arteries in 129 patients. Compared to the control group, the average cQFR of the RIPC group increased significantly after RIPC. Additionally, 23 patients with cardiac syndrome X (IMR > 30) were included in this study. Compared to the control group, IMR and the difference between cQFR and fQFR (cQFR-fQFR) both decreased significantly after receiving RIPC. The application of RIPC can increase coronary blood flow and improve coronary microcirculation function.https://doi.org/10.1186/s12872-023-03419-0Coronary circulationQuantitative flow ratioMicrocirculatory resistanceCoronary angiography |
| spellingShingle | Zhen-Zhou Zhao En Li Xue-Jie Li Quan Guo Qing-Bo Shi Mu-Wei Li Effects of remote ischemic preconditioning on coronary blood flow and microcirculation BMC Cardiovascular Disorders Coronary circulation Quantitative flow ratio Microcirculatory resistance Coronary angiography |
| title | Effects of remote ischemic preconditioning on coronary blood flow and microcirculation |
| title_full | Effects of remote ischemic preconditioning on coronary blood flow and microcirculation |
| title_fullStr | Effects of remote ischemic preconditioning on coronary blood flow and microcirculation |
| title_full_unstemmed | Effects of remote ischemic preconditioning on coronary blood flow and microcirculation |
| title_short | Effects of remote ischemic preconditioning on coronary blood flow and microcirculation |
| title_sort | effects of remote ischemic preconditioning on coronary blood flow and microcirculation |
| topic | Coronary circulation Quantitative flow ratio Microcirculatory resistance Coronary angiography |
| url | https://doi.org/10.1186/s12872-023-03419-0 |
| work_keys_str_mv | AT zhenzhouzhao effectsofremoteischemicpreconditioningoncoronarybloodflowandmicrocirculation AT enli effectsofremoteischemicpreconditioningoncoronarybloodflowandmicrocirculation AT xuejieli effectsofremoteischemicpreconditioningoncoronarybloodflowandmicrocirculation AT quanguo effectsofremoteischemicpreconditioningoncoronarybloodflowandmicrocirculation AT qingboshi effectsofremoteischemicpreconditioningoncoronarybloodflowandmicrocirculation AT muweili effectsofremoteischemicpreconditioningoncoronarybloodflowandmicrocirculation |