Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study.
Epidemiological studies relating maternal 25-hydroxyvitamin D (25OHD) with gestational diabetes mellitus (GDM) and mode of delivery have shown controversial results. We examined if maternal 25OHD status was associated with plasma glucose concentrations, risks of GDM and caesarean section in the Grow...
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| Format: | Article |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4646602?pdf=render |
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| author | See Ling Loy Ngee Lek Fabian Yap Shu E Soh Natarajan Padmapriya Kok Hian Tan Arijit Biswas George Seow Heong Yeo Kenneth Kwek Peter D Gluckman Keith M Godfrey Seang Mei Saw Falk Müller-Riemenschneider Yap-Seng Chong Mary Foong-Fong Chong Jerry Kok Yen Chan Growing Up in Singapore Towards Healthy Outcomes (GUSTO) study group |
| author_facet | See Ling Loy Ngee Lek Fabian Yap Shu E Soh Natarajan Padmapriya Kok Hian Tan Arijit Biswas George Seow Heong Yeo Kenneth Kwek Peter D Gluckman Keith M Godfrey Seang Mei Saw Falk Müller-Riemenschneider Yap-Seng Chong Mary Foong-Fong Chong Jerry Kok Yen Chan Growing Up in Singapore Towards Healthy Outcomes (GUSTO) study group |
| author_sort | See Ling Loy |
| collection | DOAJ |
| description | Epidemiological studies relating maternal 25-hydroxyvitamin D (25OHD) with gestational diabetes mellitus (GDM) and mode of delivery have shown controversial results. We examined if maternal 25OHD status was associated with plasma glucose concentrations, risks of GDM and caesarean section in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study.Plasma 25OHD concentrations, fasting glucose (FG) and 2-hour postprandial glucose (2HPPG) concentrations were measured in 940 women from a Singapore mother-offspring cohort study at 26-28 weeks' gestation. 25OHD inadequacy and adequacy were defined based on concentrations of 25OHD ≤75nmol/l and >75nmol/l respectively. Mode of delivery was obtained from hospital records. Multiple linear regression was performed to examine the association between 25OHD status and glucose concentrations, while multiple logistic regression was performed to examine the association of 25OHD status with risks of GDM and caesarean section.In total, 388 (41.3%) women had 25OHD inadequacy. Of these, 131 (33.8%), 155 (39.9%) and 102 (26.3%) were Chinese, Malay and Indian respectively. After adjustment for confounders, maternal 25OHD inadequacy was associated with higher FG concentrations (β = 0.08mmol/l, 95% Confidence Interval (CI) = 0.01, 0.14), but not 2HPPG concentrations and risk of GDM. A trend between 25OHD inadequacy and higher likelihood of emergency caesarean section (Odds Ratio (OR) = 1.39, 95% CI = 0.95, 2.05) was observed. On stratification by ethnicity, the association with higher FG concentrations was significant in Malay women (β = 0.19mmol/l, 95% CI = 0.04, 0.33), while risk of emergency caesarean section was greater in Chinese (OR = 1.90, 95% CI = 1.06, 3.43) and Indian women (OR = 2.41, 95% CI = 1.01, 5.73).25OHD inadequacy is prevalent in pregnant Singaporean women, particularly among the Malay and Indian women. This is associated with higher FG concentrations in Malay women, and increased risk of emergency caesarean section in Chinese and Indian women. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-14T00:46:09Z |
| publishDate | 2015-01-01 |
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| spelling | doaj.art-6ff7e39c3de94f3199edb53251f66be82022-12-22T02:22:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014223910.1371/journal.pone.0142239Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study.See Ling LoyNgee LekFabian YapShu E SohNatarajan PadmapriyaKok Hian TanArijit BiswasGeorge Seow Heong YeoKenneth KwekPeter D GluckmanKeith M GodfreySeang Mei SawFalk Müller-RiemenschneiderYap-Seng ChongMary Foong-Fong ChongJerry Kok Yen ChanGrowing Up in Singapore Towards Healthy Outcomes (GUSTO) study groupEpidemiological studies relating maternal 25-hydroxyvitamin D (25OHD) with gestational diabetes mellitus (GDM) and mode of delivery have shown controversial results. We examined if maternal 25OHD status was associated with plasma glucose concentrations, risks of GDM and caesarean section in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study.Plasma 25OHD concentrations, fasting glucose (FG) and 2-hour postprandial glucose (2HPPG) concentrations were measured in 940 women from a Singapore mother-offspring cohort study at 26-28 weeks' gestation. 25OHD inadequacy and adequacy were defined based on concentrations of 25OHD ≤75nmol/l and >75nmol/l respectively. Mode of delivery was obtained from hospital records. Multiple linear regression was performed to examine the association between 25OHD status and glucose concentrations, while multiple logistic regression was performed to examine the association of 25OHD status with risks of GDM and caesarean section.In total, 388 (41.3%) women had 25OHD inadequacy. Of these, 131 (33.8%), 155 (39.9%) and 102 (26.3%) were Chinese, Malay and Indian respectively. After adjustment for confounders, maternal 25OHD inadequacy was associated with higher FG concentrations (β = 0.08mmol/l, 95% Confidence Interval (CI) = 0.01, 0.14), but not 2HPPG concentrations and risk of GDM. A trend between 25OHD inadequacy and higher likelihood of emergency caesarean section (Odds Ratio (OR) = 1.39, 95% CI = 0.95, 2.05) was observed. On stratification by ethnicity, the association with higher FG concentrations was significant in Malay women (β = 0.19mmol/l, 95% CI = 0.04, 0.33), while risk of emergency caesarean section was greater in Chinese (OR = 1.90, 95% CI = 1.06, 3.43) and Indian women (OR = 2.41, 95% CI = 1.01, 5.73).25OHD inadequacy is prevalent in pregnant Singaporean women, particularly among the Malay and Indian women. This is associated with higher FG concentrations in Malay women, and increased risk of emergency caesarean section in Chinese and Indian women.http://europepmc.org/articles/PMC4646602?pdf=render |
| spellingShingle | See Ling Loy Ngee Lek Fabian Yap Shu E Soh Natarajan Padmapriya Kok Hian Tan Arijit Biswas George Seow Heong Yeo Kenneth Kwek Peter D Gluckman Keith M Godfrey Seang Mei Saw Falk Müller-Riemenschneider Yap-Seng Chong Mary Foong-Fong Chong Jerry Kok Yen Chan Growing Up in Singapore Towards Healthy Outcomes (GUSTO) study group Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study. PLoS ONE |
| title | Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study. |
| title_full | Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study. |
| title_fullStr | Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study. |
| title_full_unstemmed | Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study. |
| title_short | Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study. |
| title_sort | association of maternal vitamin d status with glucose tolerance and caesarean section in a multi ethnic asian cohort the growing up in singapore towards healthy outcomes study |
| url | http://europepmc.org/articles/PMC4646602?pdf=render |
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