Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity
Mona A Hegazy,1 Ibrahim Abd ALgwad,1 Soheir Abuel Fadl,1 Mohamed Sayed Hassan,1 Laila Ahmed Rashed,2 Maha A Hussein1 1Internal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, Egypt; 2Biochemistry Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptCorrespondence:...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-05-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/serum-micro-rna-122-level-as-a-simple-noninvasive-marker-of-mafld-seve-peer-reviewed-fulltext-article-DMSO |
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| author | Hegazy MA Abd ALgwad I Abuel Fadl S Sayed Hassan M Ahmed Rashed L Hussein MA |
| author_facet | Hegazy MA Abd ALgwad I Abuel Fadl S Sayed Hassan M Ahmed Rashed L Hussein MA |
| author_sort | Hegazy MA |
| collection | DOAJ |
| description | Mona A Hegazy,1 Ibrahim Abd ALgwad,1 Soheir Abuel Fadl,1 Mohamed Sayed Hassan,1 Laila Ahmed Rashed,2 Maha A Hussein1 1Internal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, Egypt; 2Biochemistry Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptCorrespondence: Mona A HegazyInternal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptEmail monahegazy@cu.edu.egBackground: Metabolic-associated fatty liver disease (MAFLD) is a common disease worldwide. Micro-RNA-122 is known to be the most abundant micro-RNA expressed in the liver.Objective: To evaluate the association of micro-RNA-122 and the degree of steatosis and fibrosis in obese patients with MAFLD.Methods: The study included 120 obese Egyptian patients with MAFLD, which were diagnosed and classified according to ultra-sonographic liver findings. All patients enrolled in the study were subjected to thorough clinical examination and laboratory investigations (serum micro-RNA-122 levels by PCR, lipid profile, liver biochemistry, and functions). Fibro-scan was used to assess the level of fibrosis.Results: There was a significant increase in levels of micro-RNA-122 in obese patients with MAFLD compared to controls (p< 0.001). Micro-RNA-122 level was lower in patients with mild liver steatosis than patients with moderate or severe steatosis (p< 0.001). It was lower in patients with a mild degree of fibrosis than those with mild or moderate fibrosis (p< 0.001). Micro-RNA-122 was significantly positively correlated with low-density cholesterol and triglycerides level, and liver enzymes, and negatively correlated to high-density cholesterol (p< 0.001).Conclusion: Serum micro-RNA-122 could be a useful predictor of assessing MAFLD severity regarding level of steatosis or fibrosis.Keywords: MAFLD, micro RNA, steatosis and fibrosis |
| first_indexed | 2024-04-10T17:55:03Z |
| format | Article |
| id | doaj.art-6ff86db902d8408f87f50781016f7d26 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T17:55:03Z |
| publishDate | 2021-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-6ff86db902d8408f87f50781016f7d262023-02-02T19:00:03ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072021-05-01Volume 142247225464927Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD SeverityHegazy MAAbd ALgwad IAbuel Fadl SSayed Hassan MAhmed Rashed LHussein MAMona A Hegazy,1 Ibrahim Abd ALgwad,1 Soheir Abuel Fadl,1 Mohamed Sayed Hassan,1 Laila Ahmed Rashed,2 Maha A Hussein1 1Internal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, Egypt; 2Biochemistry Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptCorrespondence: Mona A HegazyInternal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptEmail monahegazy@cu.edu.egBackground: Metabolic-associated fatty liver disease (MAFLD) is a common disease worldwide. Micro-RNA-122 is known to be the most abundant micro-RNA expressed in the liver.Objective: To evaluate the association of micro-RNA-122 and the degree of steatosis and fibrosis in obese patients with MAFLD.Methods: The study included 120 obese Egyptian patients with MAFLD, which were diagnosed and classified according to ultra-sonographic liver findings. All patients enrolled in the study were subjected to thorough clinical examination and laboratory investigations (serum micro-RNA-122 levels by PCR, lipid profile, liver biochemistry, and functions). Fibro-scan was used to assess the level of fibrosis.Results: There was a significant increase in levels of micro-RNA-122 in obese patients with MAFLD compared to controls (p< 0.001). Micro-RNA-122 level was lower in patients with mild liver steatosis than patients with moderate or severe steatosis (p< 0.001). It was lower in patients with a mild degree of fibrosis than those with mild or moderate fibrosis (p< 0.001). Micro-RNA-122 was significantly positively correlated with low-density cholesterol and triglycerides level, and liver enzymes, and negatively correlated to high-density cholesterol (p< 0.001).Conclusion: Serum micro-RNA-122 could be a useful predictor of assessing MAFLD severity regarding level of steatosis or fibrosis.Keywords: MAFLD, micro RNA, steatosis and fibrosishttps://www.dovepress.com/serum-micro-rna-122-level-as-a-simple-noninvasive-marker-of-mafld-seve-peer-reviewed-fulltext-article-DMSOmafldmicro rnasteatosis and fibrosis |
| spellingShingle | Hegazy MA Abd ALgwad I Abuel Fadl S Sayed Hassan M Ahmed Rashed L Hussein MA Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity Diabetes, Metabolic Syndrome and Obesity mafld micro rna steatosis and fibrosis |
| title | Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity |
| title_full | Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity |
| title_fullStr | Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity |
| title_full_unstemmed | Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity |
| title_short | Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity |
| title_sort | serum micro rna 122 level as a simple noninvasive marker of mafld severity |
| topic | mafld micro rna steatosis and fibrosis |
| url | https://www.dovepress.com/serum-micro-rna-122-level-as-a-simple-noninvasive-marker-of-mafld-seve-peer-reviewed-fulltext-article-DMSO |
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