L-NAC reverses of the adverse effects of fentanyl infusion on ventilation and blood-gas chemistry

L-NAC reverses of the adverse effects of fentanyl infusion on ventilation and blood-gas chemistry

There is an urgent need for development of drugs that are able to reverse the adverse effects of opioids on breathing and arterial blood-gas (ABG) chemistry while preserving opioid analgesia. The present study describes the effects of bolus injections of N-acetyl-L-cysteine (L-NAC, 500 μmol/kg, IV)...

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Bibliographic Details
Main Authors: Paulina M. Getsy, Santhosh M. Baby, Walter J. May, Tristan H.J. Lewis, James N. Bates, Yee-Hsee Hsieh, Benjamin Gaston, Stephen J. Lewis
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Fentanyl infusion
Opioid-induced respiratory depression
N-acetyl-L-cysteine
Rats
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222006667

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