The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness

The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness

FLT3 and c-KIT are crucial regulators of hematopoietic stem and progenitor cells. We investigated the role of STS1 and STS2 on FLT3 and c-KIT phosphorylation, activity, and function in normal and stress-induced hematopoiesis. STS1/STS2-deficient mice show a profound expansion of multipotent progenit...

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Bibliographic Details
Main Authors: Jing Zhang, Olesya Vakhrusheva, Srinivasa Rao Bandi, Özlem Demirel, Julhash U. Kazi, Ramona Gomes Fernandes, Katja Jakobi, Astrid Eichler, Lars Rönnstrand, Michael A. Rieger, Nick Carpino, Hubert Serve, Christian H. Brandts
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115002404

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