Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow’s Milk Protein Allergy
Although extensively hydrolyzed formula is widely accepted for managing cow’s milk protein allergy (CMPA) long-term, there is a lack of evidence on its short-term efficacy. This study’s objective was to investigate the short-term symptom changes (within 3–6 weeks) of infants diagnosed with CMPA and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/7/1677 |
| _version_ | 1797607266444115968 |
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| author | Michael J. Wilsey Jared Florio Jesse Beacker Luke Lamos Jessica V. Baran Lea Oliveros Panida Sriaroon Jerry M. Brown Jon A. Vanderhoof |
| author_facet | Michael J. Wilsey Jared Florio Jesse Beacker Luke Lamos Jessica V. Baran Lea Oliveros Panida Sriaroon Jerry M. Brown Jon A. Vanderhoof |
| author_sort | Michael J. Wilsey |
| collection | DOAJ |
| description | Although extensively hydrolyzed formula is widely accepted for managing cow’s milk protein allergy (CMPA) long-term, there is a lack of evidence on its short-term efficacy. This study’s objective was to investigate the short-term symptom changes (within 3–6 weeks) of infants diagnosed with CMPA and managed with extensively hydrolyzed formula containing Lactobacillus <i>rhamnosus</i> at their subsequent physician visit. Healthcare providers treating 202 patients diagnosed with CMPA under six months old completed de-identified surveys, which were then analyzed in this prospective study. After their first visit, the patients were started on extensively hydrolyzed formula, and their baseline symptoms were scored on a severity scale of 0–3. Patients were then reevaluated at their next follow-up visit to assess changes in symptom severity. The study found statistically significant improvements in gastrointestinal (93%), skin (83%), respiratory (73%), and uncategorized symptoms (90%). These symptom improvements were consistent across different follow-up visit durations. This study is the largest prospective analysis conducted in the United States evaluating short-term change in CMPA symptoms severity in infants under six months old using extensively hydrolyzed formula. These findings suggest that extensively hydrolyzed formula is associated with clinical symptom relief, which is often noticeable by the next follow-up visit. However, additional randomized control trials are needed to validate these results. |
| first_indexed | 2024-03-11T05:27:48Z |
| format | Article |
| id | doaj.art-6ffc19f56f514c58984007cc75a9b631 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T05:27:48Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6ffc19f56f514c58984007cc75a9b6312023-11-17T17:20:27ZengMDPI AGNutrients2072-66432023-03-01157167710.3390/nu15071677Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow’s Milk Protein AllergyMichael J. Wilsey0Jared Florio1Jesse Beacker2Luke Lamos3Jessica V. Baran4Lea Oliveros5Panida Sriaroon6Jerry M. Brown7Jon A. Vanderhoof8Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USAOffice of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL 33431, USAOffice of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL 33431, USAOffice of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL 33431, USAOffice of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL 33431, USAPediatric Gastroenterology, Hepatology, and Nutrition of Florida, St. Petersburg, FL 33701, USADepartment of Pediatric Allergy and Immunology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USAOffice of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL 33431, USADepartment of Gastroenterology Hepatology and Nutrition, Boys Town Hospital, Boys Town, NE 68010, USAAlthough extensively hydrolyzed formula is widely accepted for managing cow’s milk protein allergy (CMPA) long-term, there is a lack of evidence on its short-term efficacy. This study’s objective was to investigate the short-term symptom changes (within 3–6 weeks) of infants diagnosed with CMPA and managed with extensively hydrolyzed formula containing Lactobacillus <i>rhamnosus</i> at their subsequent physician visit. Healthcare providers treating 202 patients diagnosed with CMPA under six months old completed de-identified surveys, which were then analyzed in this prospective study. After their first visit, the patients were started on extensively hydrolyzed formula, and their baseline symptoms were scored on a severity scale of 0–3. Patients were then reevaluated at their next follow-up visit to assess changes in symptom severity. The study found statistically significant improvements in gastrointestinal (93%), skin (83%), respiratory (73%), and uncategorized symptoms (90%). These symptom improvements were consistent across different follow-up visit durations. This study is the largest prospective analysis conducted in the United States evaluating short-term change in CMPA symptoms severity in infants under six months old using extensively hydrolyzed formula. These findings suggest that extensively hydrolyzed formula is associated with clinical symptom relief, which is often noticeable by the next follow-up visit. However, additional randomized control trials are needed to validate these results.https://www.mdpi.com/2072-6643/15/7/1677cow’s milk protein allergyextensively hydrolyzed formula (eHF)food allergyLactobacillus rhamnosus (LGG)zsmoments |
| spellingShingle | Michael J. Wilsey Jared Florio Jesse Beacker Luke Lamos Jessica V. Baran Lea Oliveros Panida Sriaroon Jerry M. Brown Jon A. Vanderhoof Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow’s Milk Protein Allergy Nutrients cow’s milk protein allergy extensively hydrolyzed formula (eHF) food allergy Lactobacillus rhamnosus (LGG) zsmoments |
| title | Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow’s Milk Protein Allergy |
| title_full | Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow’s Milk Protein Allergy |
| title_fullStr | Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow’s Milk Protein Allergy |
| title_full_unstemmed | Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow’s Milk Protein Allergy |
| title_short | Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow’s Milk Protein Allergy |
| title_sort | extensively hydrolyzed formula improves allergic symptoms in the short term in infants with suspected cow s milk protein allergy |
| topic | cow’s milk protein allergy extensively hydrolyzed formula (eHF) food allergy Lactobacillus rhamnosus (LGG) zsmoments |
| url | https://www.mdpi.com/2072-6643/15/7/1677 |
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