Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease
<i>Background and Objectives:</i> Hyperuricemia and liver steatosis are risk factors for cardiovascular diseases and mortality. The use of natural compounds could be a safe and effective alternative to drugs for the treatment of fatty liver and hyperuricemia. Polyphenolic fraction of Cit...
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MDPI AG
2022-11-01
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| Online Access: | https://www.mdpi.com/1648-9144/58/12/1728 |
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| author | Yvelise Ferro Samantha Maurotti Elisa Mazza Roberta Pujia Angela Sciacqua Vincenzo Musolino Vincenzo Mollace Arturo Pujia Tiziana Montalcini |
| author_facet | Yvelise Ferro Samantha Maurotti Elisa Mazza Roberta Pujia Angela Sciacqua Vincenzo Musolino Vincenzo Mollace Arturo Pujia Tiziana Montalcini |
| author_sort | Yvelise Ferro |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Hyperuricemia and liver steatosis are risk factors for cardiovascular diseases and mortality. The use of natural compounds could be a safe and effective alternative to drugs for the treatment of fatty liver and hyperuricemia. Polyphenolic fraction of Citrus Bergamia in association with the extract of Cynara Cardunculus, as nutraceutical, is able to reduce body weight, hepatic steatosis and markers of oxidative stress. Then, we performed a secondary analysis of a double-blind placebo-controlled trial to examine the effects of this nutraceutical on serum uric acid levels in adults with fatty liver. <i>Materials and Methods:</i> The study included 94 individuals with hepatic steatosis. For six weeks, the intervention group was given a nutraceutical (300 mg/day) comprising a Bergamot polyphenol fraction and Cynara Cardunculus extract. The control group received a daily pill of placebo. Serum uric acid, lipids, glucose and anthropometric parameters were assessed at baseline and after 6 weeks. <i>Results:</i> We found a greater reduction in serum uric acid in the participants taking the nutraceutical rather than placebo (−0.1 ± 0.7 mg/dL vs. 0.3 ± 0.7 mg/dL, <i>p</i> = 0.004), and especially in those with moderate/severe hepatic steatosis also after adjustment for confounding variables. In addition, we analysed the two groups according to tertiles of uric acid concentration. Among participants taking the nutraceutical, we found in those with the highest baseline serum uric acid (>5.4 mg/dL) the greater reduction compared to the lowest baseline uric acid (−7.8% vs. +4.9%; adjusted <i>p</i> = 0.04). The stepwise multivariable analysis confirmed the association between the absolute serum uric acid change and nutraceutical treatment (B = −0.43; <i>p</i> = 0.004). <i>Conclusions:</i> A nutraceutical containing bioactive components from bergamot and wild cardoon reduced serum uric acid during 6 weeks in adults with fatty liver. Future investigations are needed to evaluate the efficacy of this nutraceutical in the treatment of hyperuricaemia. |
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| issn | 1010-660X 1648-9144 |
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| spelling | doaj.art-6ffc9c7f6429433fa5adcec1b9ed25862023-11-24T16:31:40ZengMDPI AGMedicina1010-660X1648-91442022-11-015812172810.3390/medicina58121728Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver DiseaseYvelise Ferro0Samantha Maurotti1Elisa Mazza2Roberta Pujia3Angela Sciacqua4Vincenzo Musolino5Vincenzo Mollace6Arturo Pujia7Tiziana Montalcini8Department of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, ItalyDepartment of Clinical and Experimental Medicine, University Magna Grecia, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, ItalyIRC-FSH-Pharmaceutical Biology-Department of Health Sciences, University Magna Grecia, 88100 Catanzaro, ItalyDepartment of Health Science, University Magna Grecia, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, ItalyDepartment of Clinical and Experimental Medicine, University Magna Grecia, 88100 Catanzaro, Italy<i>Background and Objectives:</i> Hyperuricemia and liver steatosis are risk factors for cardiovascular diseases and mortality. The use of natural compounds could be a safe and effective alternative to drugs for the treatment of fatty liver and hyperuricemia. Polyphenolic fraction of Citrus Bergamia in association with the extract of Cynara Cardunculus, as nutraceutical, is able to reduce body weight, hepatic steatosis and markers of oxidative stress. Then, we performed a secondary analysis of a double-blind placebo-controlled trial to examine the effects of this nutraceutical on serum uric acid levels in adults with fatty liver. <i>Materials and Methods:</i> The study included 94 individuals with hepatic steatosis. For six weeks, the intervention group was given a nutraceutical (300 mg/day) comprising a Bergamot polyphenol fraction and Cynara Cardunculus extract. The control group received a daily pill of placebo. Serum uric acid, lipids, glucose and anthropometric parameters were assessed at baseline and after 6 weeks. <i>Results:</i> We found a greater reduction in serum uric acid in the participants taking the nutraceutical rather than placebo (−0.1 ± 0.7 mg/dL vs. 0.3 ± 0.7 mg/dL, <i>p</i> = 0.004), and especially in those with moderate/severe hepatic steatosis also after adjustment for confounding variables. In addition, we analysed the two groups according to tertiles of uric acid concentration. Among participants taking the nutraceutical, we found in those with the highest baseline serum uric acid (>5.4 mg/dL) the greater reduction compared to the lowest baseline uric acid (−7.8% vs. +4.9%; adjusted <i>p</i> = 0.04). The stepwise multivariable analysis confirmed the association between the absolute serum uric acid change and nutraceutical treatment (B = −0.43; <i>p</i> = 0.004). <i>Conclusions:</i> A nutraceutical containing bioactive components from bergamot and wild cardoon reduced serum uric acid during 6 weeks in adults with fatty liver. Future investigations are needed to evaluate the efficacy of this nutraceutical in the treatment of hyperuricaemia.https://www.mdpi.com/1648-9144/58/12/1728nutraceuticalsuric acidflavonoidsliver steatosishyperuricaemia |
| spellingShingle | Yvelise Ferro Samantha Maurotti Elisa Mazza Roberta Pujia Angela Sciacqua Vincenzo Musolino Vincenzo Mollace Arturo Pujia Tiziana Montalcini Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease Medicina nutraceuticals uric acid flavonoids liver steatosis hyperuricaemia |
| title | Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease |
| title_full | Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease |
| title_fullStr | Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed | Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease |
| title_short | Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease |
| title_sort | citrus bergamia and cynara cardunculus reduce serum uric acid in individuals with non alcoholic fatty liver disease |
| topic | nutraceuticals uric acid flavonoids liver steatosis hyperuricaemia |
| url | https://www.mdpi.com/1648-9144/58/12/1728 |
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