Proprotein Convertase Inhibition Results in Decreased Ski Proliferation, Tumorigenesis, and Metastasis

Proprotein Convertase Inhibition Results in Decreased Ski Proliferation, Tumorigenesis, and Metastasis

PACE4 is a proprotein convertase (PC) responsible for cleaving and activating proteins that contribute to enhance tumor progression. PACE4 overexpression significantly increased the susceptibility to carcinogenesis, leading to enhanced tumor cell proliferation and premature degradation of the baseme...

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Bibliographic Details
Main Authors: Daniel E. Bassi, Jirong Zhang, Jonathan Cenna, Samuel Litwin, Edna Cukierman, Andres J.P. Klein-Szanto
Format: Article
Language:English
Published: Elsevier 2010-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558610800260

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