Differential sensitivity of melanoma cell lines with <it>BRAF</it><sup><it>V600E </it></sup>mutation to the specific Raf inhibitor PLX4032

Differential sensitivity of melanoma cell lines with <it>BRAF</it><sup><it>V600E </it></sup>mutation to the specific Raf inhibitor PLX4032

<p>Abstract</p> <p>Blocking oncogenic signaling induced by the <it>BRAF</it><sup>V600E </sup>mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in melanoma...

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Main Authors: Kehoe Sarah M, Barretina Jordi G, MacConaill Laura E, Sazegar Hooman, Mok Stephen, Hsueh Teli, Guo Deliang, Wang Qi, Nazarian Ramin, Søndergaard Jonas N, Attar Narsis, von Euw Erika, Zuckerman Jonathan E, Chmielowski Bartosz, Comin-Anduix Begoña, Koya Richard C, Mischel Paul S, Lo Roger S, Ribas Antoni
Format: Article
Language:English
Published: BMC 2010-04-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/8/1/39

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