Wading pools and fading memories – place navigation in transgenic mouse models of Alzheimer’s disease
The Morris swim navigation task (‘water maze’) has been a primary research tools to assess hippocampal delpendent spatial learning and memory is rodents for three decades. Originally developed for rats, its application to mouse studies has been a tedious process, but nowadays there are more studies...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-06-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2012.00011/full |
| _version_ | 1828491202163376128 |
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| author | Heikki eTanila |
| author_facet | Heikki eTanila |
| author_sort | Heikki eTanila |
| collection | DOAJ |
| description | The Morris swim navigation task (‘water maze’) has been a primary research tools to assess hippocampal delpendent spatial learning and memory is rodents for three decades. Originally developed for rats, its application to mouse studies has been a tedious process, but nowadays there are more studies performed with the Morris swim task in mice than in rats. The task has proved to be particularly useful in demonstrating age-related memory impairment in transgenic mouse models of Alzheimer’s disease. This review focuses on task details that are most relevant for its application to mouse studies in general and characteristic patterns of impaired performance in Alzheimer model mice as compared with rodents sustaining hippocampal lesions. |
| first_indexed | 2024-12-11T10:58:17Z |
| format | Article |
| id | doaj.art-7001220be81447aabbbc28fe28db883e |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-11T10:58:17Z |
| publishDate | 2012-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-7001220be81447aabbbc28fe28db883e2022-12-22T01:09:59ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652012-06-01410.3389/fnagi.2012.0001126042Wading pools and fading memories – place navigation in transgenic mouse models of Alzheimer’s diseaseHeikki eTanila0University of Eastern FinlandThe Morris swim navigation task (‘water maze’) has been a primary research tools to assess hippocampal delpendent spatial learning and memory is rodents for three decades. Originally developed for rats, its application to mouse studies has been a tedious process, but nowadays there are more studies performed with the Morris swim task in mice than in rats. The task has proved to be particularly useful in demonstrating age-related memory impairment in transgenic mouse models of Alzheimer’s disease. This review focuses on task details that are most relevant for its application to mouse studies in general and characteristic patterns of impaired performance in Alzheimer model mice as compared with rodents sustaining hippocampal lesions.http://journal.frontiersin.org/Journal/10.3389/fnagi.2012.00011/fullPresenilin-1spatial memoryamyloid precursor proteinamyloid-betatau |
| spellingShingle | Heikki eTanila Wading pools and fading memories – place navigation in transgenic mouse models of Alzheimer’s disease Frontiers in Aging Neuroscience Presenilin-1 spatial memory amyloid precursor protein amyloid-beta tau |
| title | Wading pools and fading memories – place navigation in transgenic mouse models of Alzheimer’s disease |
| title_full | Wading pools and fading memories – place navigation in transgenic mouse models of Alzheimer’s disease |
| title_fullStr | Wading pools and fading memories – place navigation in transgenic mouse models of Alzheimer’s disease |
| title_full_unstemmed | Wading pools and fading memories – place navigation in transgenic mouse models of Alzheimer’s disease |
| title_short | Wading pools and fading memories – place navigation in transgenic mouse models of Alzheimer’s disease |
| title_sort | wading pools and fading memories place navigation in transgenic mouse models of alzheimer s disease |
| topic | Presenilin-1 spatial memory amyloid precursor protein amyloid-beta tau |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2012.00011/full |
| work_keys_str_mv | AT heikkietanila wadingpoolsandfadingmemoriesplacenavigationintransgenicmousemodelsofalzheimersdisease |