The Effect of Quisinostat as the HDAC Inhibitor on Migration
Background and Aim: Cancer cannot be explained only by genetic alterations but involves epigenetic processes. Modifying histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance between Histone Deacetylases (HDAC) and Histone Acetyltransfer...
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| Format: | Article |
| Language: | fas |
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Arak Medical University
2021-08-01
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| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://jams.arakmu.ac.ir/article-1-6668-en.html |
| _version_ | 1818157117597548544 |
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| author | Marjan Hajimoradi Javarsiani Javad Sajedianfard Shagayegh Haghjooy Javanmard |
| author_facet | Marjan Hajimoradi Javarsiani Javad Sajedianfard Shagayegh Haghjooy Javanmard |
| author_sort | Marjan Hajimoradi Javarsiani |
| collection | DOAJ |
| description | Background and Aim: Cancer cannot be explained only by genetic alterations but involves epigenetic processes. Modifying histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance between Histone Deacetylases (HDAC) and Histone Acetyltransferases (HAT). The HDACs expression and activity could be involved in several tumorigenesis mechanisms, so their inhibition induces cancer cell cycle arrest and migration.
Methods & Materials: Quisinostat is a novel promising second-generation HDAC inhibitor class of hydroxamic acid with high cellular potency towards classes I and II HDACs. Therefore, its low IC50 (<0.5nM) and bioavailability have been chosen to carry out our studies. Cancer cells were treated with Quiznos at nM200, and cell migration was measured by fluorescent microscopy.
Ethical Considerations: This study was the result of a preliminary study of Shiraz University (Code: 96GCU3M1293).
Results: The data showed that treatment of cancer cells with Quiznos significantly (P<0.05) reduced cell migration. DMSO did not affect reducing cell migration.
Conclusion: In this project try to explore the possible therapeutic application of this HDAC inhibitor against colon cancer. This study showed Quisinostat exerts broad-spectrum antiproliferative activity and migration. |
| first_indexed | 2024-12-11T15:09:06Z |
| format | Article |
| id | doaj.art-7002831d159b4e04978c5392d1651ced |
| institution | Directory Open Access Journal |
| issn | 1735-5338 2008-644X |
| language | fas |
| last_indexed | 2024-12-11T15:09:06Z |
| publishDate | 2021-08-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj.art-7002831d159b4e04978c5392d1651ced2022-12-22T01:00:48ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2021-08-01243450457The Effect of Quisinostat as the HDAC Inhibitor on MigrationMarjan Hajimoradi Javarsiani0Javad Sajedianfard1Shagayegh Haghjooy Javanmard2 Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. Background and Aim: Cancer cannot be explained only by genetic alterations but involves epigenetic processes. Modifying histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance between Histone Deacetylases (HDAC) and Histone Acetyltransferases (HAT). The HDACs expression and activity could be involved in several tumorigenesis mechanisms, so their inhibition induces cancer cell cycle arrest and migration. Methods & Materials: Quisinostat is a novel promising second-generation HDAC inhibitor class of hydroxamic acid with high cellular potency towards classes I and II HDACs. Therefore, its low IC50 (<0.5nM) and bioavailability have been chosen to carry out our studies. Cancer cells were treated with Quiznos at nM200, and cell migration was measured by fluorescent microscopy. Ethical Considerations: This study was the result of a preliminary study of Shiraz University (Code: 96GCU3M1293). Results: The data showed that treatment of cancer cells with Quiznos significantly (P<0.05) reduced cell migration. DMSO did not affect reducing cell migration. Conclusion: In this project try to explore the possible therapeutic application of this HDAC inhibitor against colon cancer. This study showed Quisinostat exerts broad-spectrum antiproliferative activity and migration.http://jams.arakmu.ac.ir/article-1-6668-en.htmlhdacquisinostatcancer cellsmigration |
| spellingShingle | Marjan Hajimoradi Javarsiani Javad Sajedianfard Shagayegh Haghjooy Javanmard The Effect of Quisinostat as the HDAC Inhibitor on Migration Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk hdac quisinostat cancer cells migration |
| title | The Effect of Quisinostat as the HDAC Inhibitor on Migration |
| title_full | The Effect of Quisinostat as the HDAC Inhibitor on Migration |
| title_fullStr | The Effect of Quisinostat as the HDAC Inhibitor on Migration |
| title_full_unstemmed | The Effect of Quisinostat as the HDAC Inhibitor on Migration |
| title_short | The Effect of Quisinostat as the HDAC Inhibitor on Migration |
| title_sort | effect of quisinostat as the hdac inhibitor on migration |
| topic | hdac quisinostat cancer cells migration |
| url | http://jams.arakmu.ac.ir/article-1-6668-en.html |
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