RETRACTED: Forensic applications and genetic characterization of Liaoning Han population revealed by extended set of autosomal STRs
ABSTRACT Background Microsatellites or short tandem repeats (STRs) are considered the gold standard for forensic investigations and autosomal STRs are used for routine forensic personal identification. Aim To provide a precise population database on an extended set of STRs which has never been done...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-12-01
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| Series: | Molecular Genetics & Genomic Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mgg3.1517 |
| _version_ | 1797301261521911808 |
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| author | Jiang Du Yefang Diao Allah Rakha Fuad Ameen Muneera D. F. AlKahtani Atif Adnan |
| author_facet | Jiang Du Yefang Diao Allah Rakha Fuad Ameen Muneera D. F. AlKahtani Atif Adnan |
| author_sort | Jiang Du |
| collection | DOAJ |
| description | ABSTRACT Background Microsatellites or short tandem repeats (STRs) are considered the gold standard for forensic investigations and autosomal STRs are used for routine forensic personal identification. Aim To provide a precise population database on an extended set of STRs which has never been done before and explore the forensic characteristics of 20 autosomal STRs. Subjects and methods In the current study, we explored the genetic characteristics of 20 STRs loci in 1138 unrelated Han individuals using Goldeneye® 20A multiplex amplification system kit in the Liaoning Han population. Additionally, phylogenetic analysis based on the Nei's standard genetic distance was performed between the Han population and other relevant populations. Results A total of 253 alleles were observed while allelic frequencies ranged from 0.00043 to 0.5369. The combined discrimination power was 99.99999999999999999999789% and the combined exclusion power was 99.999998231%. Most of the loci were in HWE while only five pairs were out of LE. Population genetic analysis showed that the Han population has similarities with other East Asian populations. Conclusion GoldenEyeTM 20A kit detects high diversity in the Liaoning Han population. These STRs which are part of this kit can be used for forensic investigations. Population genetic analysis showed that the Han population is different from the minority populations of Xinjiang. |
| first_indexed | 2024-03-07T23:18:59Z |
| format | Article |
| id | doaj.art-70031be6db1a4021a726310fda04a86c |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-03-07T23:18:59Z |
| publishDate | 2020-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-70031be6db1a4021a726310fda04a86c2024-02-21T08:38:03ZengWileyMolecular Genetics & Genomic Medicine2324-92692020-12-01812n/an/a10.1002/mgg3.1517RETRACTED: Forensic applications and genetic characterization of Liaoning Han population revealed by extended set of autosomal STRsJiang Du0Yefang Diao1Allah Rakha2Fuad Ameen3Muneera D. F. AlKahtani4Atif Adnan5Department of Pathology School of Basic Medical Sciences China Medical University Shenyang ChinaTeaching Affairs Office International Education School China Medical University Shenyang P.R. ChinaDepartment of Forensic Sciences University of Health Sciences Lahore Lahore PakistanDepartment of Botany & Microbiology College of Science King Saud University Riyadh Saudi ArabiaDepartment of Biology College of Science Princess Nourah Bint Abdulrahman University Riyadh Saudi ArabiaDepartment of Human Anatomy College of Basic Medical Science China Medical University Shenyang P.R. ChinaABSTRACT Background Microsatellites or short tandem repeats (STRs) are considered the gold standard for forensic investigations and autosomal STRs are used for routine forensic personal identification. Aim To provide a precise population database on an extended set of STRs which has never been done before and explore the forensic characteristics of 20 autosomal STRs. Subjects and methods In the current study, we explored the genetic characteristics of 20 STRs loci in 1138 unrelated Han individuals using Goldeneye® 20A multiplex amplification system kit in the Liaoning Han population. Additionally, phylogenetic analysis based on the Nei's standard genetic distance was performed between the Han population and other relevant populations. Results A total of 253 alleles were observed while allelic frequencies ranged from 0.00043 to 0.5369. The combined discrimination power was 99.99999999999999999999789% and the combined exclusion power was 99.999998231%. Most of the loci were in HWE while only five pairs were out of LE. Population genetic analysis showed that the Han population has similarities with other East Asian populations. Conclusion GoldenEyeTM 20A kit detects high diversity in the Liaoning Han population. These STRs which are part of this kit can be used for forensic investigations. Population genetic analysis showed that the Han population is different from the minority populations of Xinjiang.https://doi.org/10.1002/mgg3.1517forensic geneticsgenetic structureGoldenEyeTM 20Ahanliaoning |
| spellingShingle | Jiang Du Yefang Diao Allah Rakha Fuad Ameen Muneera D. F. AlKahtani Atif Adnan RETRACTED: Forensic applications and genetic characterization of Liaoning Han population revealed by extended set of autosomal STRs Molecular Genetics & Genomic Medicine forensic genetics genetic structure GoldenEyeTM 20A han liaoning |
| title | RETRACTED: Forensic applications and genetic characterization of Liaoning Han population revealed by extended set of autosomal STRs |
| title_full | RETRACTED: Forensic applications and genetic characterization of Liaoning Han population revealed by extended set of autosomal STRs |
| title_fullStr | RETRACTED: Forensic applications and genetic characterization of Liaoning Han population revealed by extended set of autosomal STRs |
| title_full_unstemmed | RETRACTED: Forensic applications and genetic characterization of Liaoning Han population revealed by extended set of autosomal STRs |
| title_short | RETRACTED: Forensic applications and genetic characterization of Liaoning Han population revealed by extended set of autosomal STRs |
| title_sort | retracted forensic applications and genetic characterization of liaoning han population revealed by extended set of autosomal strs |
| topic | forensic genetics genetic structure GoldenEyeTM 20A han liaoning |
| url | https://doi.org/10.1002/mgg3.1517 |
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