Current and Novel Inhibitors of HIV Protease

Current and Novel Inhibitors of HIV Protease

The design, development and clinical success of HIV protease inhibitors represent one of the most remarkable achievements of molecular medicine. This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, sid...

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Bibliographic Details
Main Authors: Jan Konvalinka, Ladislav Machala, Pavlína Řezáčová, Jana Pokorná
Format: Article
Language:English
Published: MDPI AG 2009-12-01
Series:Viruses
Subjects:
HIV protease
protease inhibitors
HAART
resistance development
pharmacokinetic boosting
protease dimerization
alternative inhibitors
Online Access:http://www.mdpi.com/1999-4915/1/3/1209/

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http://www.mdpi.com/1999-4915/1/3/1209/

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