Mapping multiplex hubs in human functional brain networks
Typical brain networks consist of many peripheral regions and a few highly centralones, i.e. hubs, playing key functional roles in cerebral inter-regional interactions. Studieshave shown that networks, obtained from the analysis of specific frequency components ofbrain activity, present peculiar arc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-07-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00326/full |
| _version_ | 1818259692367904768 |
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| author | Alex Arenas Manlio De Domenico Shuntaro Sasai |
| author_facet | Alex Arenas Manlio De Domenico Shuntaro Sasai |
| author_sort | Alex Arenas |
| collection | DOAJ |
| description | Typical brain networks consist of many peripheral regions and a few highly centralones, i.e. hubs, playing key functional roles in cerebral inter-regional interactions. Studieshave shown that networks, obtained from the analysis of specific frequency components ofbrain activity, present peculiar architectures with unique profiles of region centrality. However,the identification of hubs in networks built from different frequency bands simultaneouslyis still a challenging problem, remaining largely unexplored. Here we identify eachfrequency component with one layer of a multiplex network and face this challenge by exploitingthe recent advances in the analysis of multiplex topologies. First, we show that eachfrequency band carries unique topological information, fundamental to accurately modelbrain functional networks. We then demonstrate that hubs in the multiplex network, in generaldifferent from those ones obtained after discarding or aggregating the measured signalsas usual, provide a more accurate map of brain’s most important functional regions, allowingto distinguish between healthy and schizophrenic populations better than conventionalnetwork approaches. |
| first_indexed | 2024-12-12T18:19:29Z |
| format | Article |
| id | doaj.art-70059b4172dc47b68ea640098a6d33b9 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T18:19:29Z |
| publishDate | 2016-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-70059b4172dc47b68ea640098a6d33b92022-12-22T00:16:10ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2016-07-011010.3389/fnins.2016.00326205256Mapping multiplex hubs in human functional brain networksAlex Arenas0Manlio De Domenico1Shuntaro Sasai2URVURVUniversity of Wisconsin - MadisonTypical brain networks consist of many peripheral regions and a few highly centralones, i.e. hubs, playing key functional roles in cerebral inter-regional interactions. Studieshave shown that networks, obtained from the analysis of specific frequency components ofbrain activity, present peculiar architectures with unique profiles of region centrality. However,the identification of hubs in networks built from different frequency bands simultaneouslyis still a challenging problem, remaining largely unexplored. Here we identify eachfrequency component with one layer of a multiplex network and face this challenge by exploitingthe recent advances in the analysis of multiplex topologies. First, we show that eachfrequency band carries unique topological information, fundamental to accurately modelbrain functional networks. We then demonstrate that hubs in the multiplex network, in generaldifferent from those ones obtained after discarding or aggregating the measured signalsas usual, provide a more accurate map of brain’s most important functional regions, allowingto distinguish between healthy and schizophrenic populations better than conventionalnetwork approaches.http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00326/fullSchizophreniaMultiplex NetworksFrequency bandsBrain fMRImultiplex hubs |
| spellingShingle | Alex Arenas Manlio De Domenico Shuntaro Sasai Mapping multiplex hubs in human functional brain networks Frontiers in Neuroscience Schizophrenia Multiplex Networks Frequency bands Brain fMRI multiplex hubs |
| title | Mapping multiplex hubs in human functional brain networks |
| title_full | Mapping multiplex hubs in human functional brain networks |
| title_fullStr | Mapping multiplex hubs in human functional brain networks |
| title_full_unstemmed | Mapping multiplex hubs in human functional brain networks |
| title_short | Mapping multiplex hubs in human functional brain networks |
| title_sort | mapping multiplex hubs in human functional brain networks |
| topic | Schizophrenia Multiplex Networks Frequency bands Brain fMRI multiplex hubs |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00326/full |
| work_keys_str_mv | AT alexarenas mappingmultiplexhubsinhumanfunctionalbrainnetworks AT manliodedomenico mappingmultiplexhubsinhumanfunctionalbrainnetworks AT shuntarosasai mappingmultiplexhubsinhumanfunctionalbrainnetworks |