Network analysis and experimental verification of tanshinone ⅡA in treatment of autoimmune hepatitis

Network analysis and experimental verification of tanshinone ⅡA in treatment of autoimmune hepatitis

Objective To analyze the relationship between potential targets and signaling pathways of tanshinone Ⅱ A (Tan Ⅱ A) in the treatment of autoimmune hepatitis (AIH) based on network pharmacological analysis, and verify the mechanism of Tan Ⅱ A on AIH by animal experiments. Methods The relevant gene tar...

Full description

Bibliographic Details
Main Authors:	HAO Jianheng, LI Zhencheng, SUN Weili
Format:	Article
Language:	zho
Published:	Editorial Office of Journal of Third Military Medical University 2022-05-01
Series:	Di-san junyi daxue xuebao
Subjects:	network pharmacology tanshinone ⅱa autoimmune hepatitis pi3k-akt signaling pathway
Online Access:	http://aammt.tmmu.edu.cn/Upload/rhtml/202111049.htm

Similar Items

Celastrol Alleviates Autoimmune Hepatitis Through the PI3K/AKT Signaling Pathway Based on Network Pharmacology and Experiments
by: Shuhui Wang, et al.
Published: (2022-03-01)

Tanshinone IIA Promoted Autophagy and Inhibited Inflammation to Alleviate Podocyte Injury in Diabetic Nephropathy
by: Li Y, et al.
Published: (2024-07-01)

TanshinoneⅡA protects acute lung injury in septic mice by regulating neutrophil extracellular traps
by: ZHANG Xiaohui, et al.
Published: (2023-01-01)

Therapeutic Effect of Costunolide in Autoimmune Hepatitis: Network Pharmacology and Experimental Validation
by: Zheng Huang, et al.
Published: (2023-02-01)

Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway
by: Yanjun Wang, et al.
Published: (2022-03-01)

Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression
by: Lili Hu, et al.
Published: (2025-01-01)

FGF4 ameliorates the liver inflammation by reducing M1 macrophage polarization in experimental autoimmune hepatitis
by: Jing Lin, et al.
Published: (2024-08-01)

Tanshinone IIA alleviates the damage of neurocytes by targeting GLUT1 in ischaemia reperfusion model (in vivo and in vitro experiments)
by: Jing Wang, et al.
Published: (2020-06-01)

Investigating the Mechanisms of Bisdemethoxycurcumin in Ulcerative Colitis: Network Pharmacology and Experimental Verification
by: Huihuan Wu, et al.
Published: (2022-12-01)

Network Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer
by: Huang S, et al.
Published: (2020-07-01)

The mechanism of Shenbing Decoction II against IgA nephropathy renal fibrosis revealed by UPLC-MS/MS, network pharmacology and experimental verification
by: Huaxi Liu, et al.
Published: (2023-11-01)

Tanshinone IIA inhibits proliferation and migration by downregulation of the PI3K/Akt pathway in small cell lung cancer cells
by: Yuxin Jiang, et al.
Published: (2024-01-01)

Activity Components from <i>Gynostemma pentaphyllum</i> for Preventing Hepatic Fibrosis and of Its Molecular Targets by Network Pharmacology Approach
by: Yumeng Zhang, et al.
Published: (2021-05-01)

An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)
by: Irum Naz, et al.
Published: (2020-06-01)

Uncovering the Effect and Mechanism of Rhizoma Corydalis on Myocardial Infarction Through an Integrated Network Pharmacology Approach and Experimental Verification
by: Jingyan Li, et al.
Published: (2022-07-01)

In silico identification and verification of Tanshinone IIA-related prognostic genes in hepatocellular carcinoma
by: Lichao Qian, et al.
Published: (2024-10-01)

Sinomenine Alleviates Rheumatoid Arthritis by Suppressing the PI3K-Akt Signaling Pathway, as Demonstrated Through Network Pharmacology, Molecular Docking, and Experimental Validation
by: Liu Q, et al.
Published: (2024-08-01)

Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim–Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer
by: Shaopu Hu, et al.
Published: (2022-03-01)

Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation
by: Yirixiati Aihaiti, et al.
Published: (2021-05-01)

Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza
by: Zhouqian Jiang, et al.
Published: (2019-03-01)

Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones
by: Xifeng Zhai, et al.
Published: (2017-01-01)

Tanshinone I inhibited growth of human chronic myeloid leukemia cells via JNK/ERK mediated apoptotic pathways
by: Siya Sun, et al.
Published: (2021-05-01)

Itaconate attenuates autoimmune hepatitis via PI3K/AKT/mTOR pathway-mediated inhibition of dendritic cell maturation and autophagy
by: Qiyu Zhang, et al.
Published: (2023-07-01)

Mechanisms of Actinidia chinensis Planch in treating colon cancer based on the integration of network pharmacology, molecular docking, and experimental verification
by: Jin-Fang Chen, et al.
Published: (2023-12-01)

Exploring the potential targets of the Abrus cantoniensis Hance in the treatment of hepatitis E based on network pharmacology
by: Ziheng Xu, et al.
Published: (2023-03-01)

Integrated network pharmacology and experimental verification to investigate the mechanisms of YYFZBJS against colorectal cancer via CDK1/PI3K/Akt signaling
by: Jinxiao Li, et al.
Published: (2022-11-01)

The mechanism of Tanshinone ⅡA on regulating EMT in cutaneous melanoma A375 cells through TAMs autophagy
by: Zhao HAN, et al.
Published: (2022-08-01)

Research and Development of Natural Product Tanshinone I: Pharmacology, Total Synthesis, and Structure Modifications
by: Xing Huang, et al.
Published: (2022-07-01)

Exploring the Mechanism of Chuanxiong Rhizoma against Thrombosis Based on Network Pharmacology, Molecular Docking and Experimental Verification
by: Shasha He, et al.
Published: (2023-09-01)

Anti-glioma Effect and Mechanism of Andrographolide on Human U251 Glioma Cells
by: Weihong CHEN, et al.
Published: (2022-12-01)

Investigation of cardiovascular protective effect of Shenmai injection by network pharmacology and pharmacological evaluation
by: Lin Li, et al.
Published: (2020-04-01)

Molecular mechanism of Ganji Fang in the treatment of hepatocellular carcinoma based on network pharmacology, molecular docking and experimental verification technology
by: Miaolun Yang, et al.
Published: (2023-01-01)

Metabolism of Tanshinone IIA, Cryptotanshinone and Tanshinone I from Radix Salvia Miltiorrhiza in Zebrafish
by: Bing Wang, et al.
Published: (2012-07-01)

Integrating network pharmacology and experimental validation to explore the effect and mechanism of AD-1 in the treatment of colorectal cancer
by: Jiawei Li, et al.
Published: (2023-05-01)

Progress of tanshinone IIA against respiratory diseases: therapeutic targets and potential mechanisms
by: Zhaohui Ding, et al.
Published: (2025-02-01)

Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer
by: Zhixuan Wu, et al.
Published: (2024-09-01)

Exploring the mechanisms of lithium neurotoxicity based on network toxicology and molecular docking
by: Wei Wei, et al.
Published: (2025-03-01)

Exploring the underlying mechanisms of fisetin in the treatment of hepatic insulin resistance via network pharmacology and in vitro validation
by: Tian Li, et al.
Published: (2023-11-01)

Integration of network pharmacology and experimental verifications reveals the Bian-Se-Tong mixture can alleviate constipation in STC rats by reducing apoptosis of Cajal cells via activating PI3K-Akt signaling pathway
by: Rong Wu, et al.
Published: (2024-04-01)

Network Pharmacology and Experimental Evidence: PI3K/AKT Signaling Pathway is Involved in the Antidepressive Roles of Chaihu Shugan San
by: Zhang S, et al.
Published: (2021-08-01)