Senile Cataract Formation Does Not Affect Crystalline Lens Thickness
Abstract Introduction Characterizing lens thickness (LT) in patients with cataracts is important for better understanding the lens aging process and for designing new intraocular lens power formulas. This study aimed to analyze the influence of common senile cataract formation on the LT, anterior (A...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-01-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40123-024-00882-6 |
| _version_ | 1797275551815172096 |
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| author | Alberto López-de la Rosa Cecilia Díez-Montero Elena Martínez-Plaza Alberto López-Miguel Miguel J. Maldonado |
| author_facet | Alberto López-de la Rosa Cecilia Díez-Montero Elena Martínez-Plaza Alberto López-Miguel Miguel J. Maldonado |
| author_sort | Alberto López-de la Rosa |
| collection | DOAJ |
| description | Abstract Introduction Characterizing lens thickness (LT) in patients with cataracts is important for better understanding the lens aging process and for designing new intraocular lens power formulas. This study aimed to analyze the influence of common senile cataract formation on the LT, anterior (ACS) and posterior (PCS) cortex space, and nuclear thickness (NT), controlling for sex, age, and axial length. Methods A cross-sectional study was performed. A consecutive sample of 603 volunteers (403 women, 200 men) aged 59.1 ± 18.8 years was recruited. The standardized Lens Opacification Classification System (LOCS)-III was used to classify eyes (randomly selected) into cataractous and non-cataractous groups. Also, they were classified according to the cataract location (presence or absence of cortical, nuclear, or posterior subcapsular cataract). Optical biometry was performed to measure LT, ACS, NT, and PCS. Propensity score was used to match participants one-to-one for sex, age, and axial length. Groups were compared using the Student’s t test or Yuen’s test. Results The four classifications divided unmatched eyes into: 361 cataractous lenses and 242 non-cataractous, 226 cortical and 377 non-cortical cataractous, 313 nuclear and 290 non-nuclear cataractous and 242 subcapsular and 361 non-subcapsular cataractous. Before matching, cataractous eyes showed significantly higher LT (4.52 ± 0.39 vs. 3.94 ± 0.46 mm, p < 0.001), ACS (0.75 ± 0.20 vs. 0.58 ± 0.23 mm, p < 0.001), NT (3.34 ± 0.23 vs. 3.18 ± 0.25 mm, p < 0.001) and PCS (0.42 ± 0.19 vs. 0.37 ± 0.19 mm, p = 0.003). Matched lens, cortical, nuclear, and subcapsular cataract samples comprised 146, 258, 182, and 226 eyes, respectively. After matching, no significant differences were observed in LT (4.34 ± 0.37 vs. 4.33 ± 0.36 mm, p = 0.94), ACS (0.72 ± 0.20 vs. 0.76 ± 0.19 mm, p = 0.08), NT (3.31 ± 0.22 vs. 3.30 ± 0.23 mm, p = 0.24) and PCS (0.42 ± 0.19 vs. 0.43 ± 0.16 mm, p = 0.79). Conclusions The presence of senile cortical, nuclear, and posterior subcapsular cataract have no effect on LT, ACS, NT, and PCS. Confounding factors should be controlled for when measuring LT and its main components. |
| first_indexed | 2024-03-07T15:16:06Z |
| format | Article |
| id | doaj.art-7007e4ec9ce14c9ba042c3f2025156ef |
| institution | Directory Open Access Journal |
| issn | 2193-8245 2193-6528 |
| language | English |
| last_indexed | 2024-03-07T15:16:06Z |
| publishDate | 2024-01-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj.art-7007e4ec9ce14c9ba042c3f2025156ef2024-03-05T17:54:05ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282024-01-0113381983010.1007/s40123-024-00882-6Senile Cataract Formation Does Not Affect Crystalline Lens ThicknessAlberto López-de la Rosa0Cecilia Díez-Montero1Elena Martínez-Plaza2Alberto López-Miguel3Miguel J. Maldonado4Instituto de Oftalmobiología Aplicada (IOBA), Universidad de ValladolidInstituto de Oftalmobiología Aplicada (IOBA), Universidad de ValladolidInstituto de Oftalmobiología Aplicada (IOBA), Universidad de ValladolidInstituto de Oftalmobiología Aplicada (IOBA), Universidad de ValladolidInstituto de Oftalmobiología Aplicada (IOBA), Universidad de ValladolidAbstract Introduction Characterizing lens thickness (LT) in patients with cataracts is important for better understanding the lens aging process and for designing new intraocular lens power formulas. This study aimed to analyze the influence of common senile cataract formation on the LT, anterior (ACS) and posterior (PCS) cortex space, and nuclear thickness (NT), controlling for sex, age, and axial length. Methods A cross-sectional study was performed. A consecutive sample of 603 volunteers (403 women, 200 men) aged 59.1 ± 18.8 years was recruited. The standardized Lens Opacification Classification System (LOCS)-III was used to classify eyes (randomly selected) into cataractous and non-cataractous groups. Also, they were classified according to the cataract location (presence or absence of cortical, nuclear, or posterior subcapsular cataract). Optical biometry was performed to measure LT, ACS, NT, and PCS. Propensity score was used to match participants one-to-one for sex, age, and axial length. Groups were compared using the Student’s t test or Yuen’s test. Results The four classifications divided unmatched eyes into: 361 cataractous lenses and 242 non-cataractous, 226 cortical and 377 non-cortical cataractous, 313 nuclear and 290 non-nuclear cataractous and 242 subcapsular and 361 non-subcapsular cataractous. Before matching, cataractous eyes showed significantly higher LT (4.52 ± 0.39 vs. 3.94 ± 0.46 mm, p < 0.001), ACS (0.75 ± 0.20 vs. 0.58 ± 0.23 mm, p < 0.001), NT (3.34 ± 0.23 vs. 3.18 ± 0.25 mm, p < 0.001) and PCS (0.42 ± 0.19 vs. 0.37 ± 0.19 mm, p = 0.003). Matched lens, cortical, nuclear, and subcapsular cataract samples comprised 146, 258, 182, and 226 eyes, respectively. After matching, no significant differences were observed in LT (4.34 ± 0.37 vs. 4.33 ± 0.36 mm, p = 0.94), ACS (0.72 ± 0.20 vs. 0.76 ± 0.19 mm, p = 0.08), NT (3.31 ± 0.22 vs. 3.30 ± 0.23 mm, p = 0.24) and PCS (0.42 ± 0.19 vs. 0.43 ± 0.16 mm, p = 0.79). Conclusions The presence of senile cortical, nuclear, and posterior subcapsular cataract have no effect on LT, ACS, NT, and PCS. Confounding factors should be controlled for when measuring LT and its main components.https://doi.org/10.1007/s40123-024-00882-6CataractCorticalLensNuclearSubcapsularThickness |
| spellingShingle | Alberto López-de la Rosa Cecilia Díez-Montero Elena Martínez-Plaza Alberto López-Miguel Miguel J. Maldonado Senile Cataract Formation Does Not Affect Crystalline Lens Thickness Ophthalmology and Therapy Cataract Cortical Lens Nuclear Subcapsular Thickness |
| title | Senile Cataract Formation Does Not Affect Crystalline Lens Thickness |
| title_full | Senile Cataract Formation Does Not Affect Crystalline Lens Thickness |
| title_fullStr | Senile Cataract Formation Does Not Affect Crystalline Lens Thickness |
| title_full_unstemmed | Senile Cataract Formation Does Not Affect Crystalline Lens Thickness |
| title_short | Senile Cataract Formation Does Not Affect Crystalline Lens Thickness |
| title_sort | senile cataract formation does not affect crystalline lens thickness |
| topic | Cataract Cortical Lens Nuclear Subcapsular Thickness |
| url | https://doi.org/10.1007/s40123-024-00882-6 |
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