EGF Stimulates Rab35 Activation and Gastric Cancer Cell Migration by Regulating DENND1A-Grb2 Complex Formation

EGF Stimulates Rab35 Activation and Gastric Cancer Cell Migration by Regulating DENND1A-Grb2 Complex Formation

Aims: The aim of this study was to reveal the specific molecular mechanisms by which DENND1A accepts EGF signaling and activates Rab35 in gastric cancer.Methods: The expression of proteins related to DENND1A was examined by western blot analysis. Activation of Rab35 was assessed by GST-pulldown. The...

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Bibliographic Details
Main Authors: Bixing Ye, Biao Duan, Wenjie Deng, Yueyuan Wang, Yan Chen, Jie Cui, Shixiu Sun, Yujie Zhang, Jun Du, Luo Gu, Lin Lin, Yurong Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
Rab35
DENND1A
Grb2
interaction
cell migration
gastric cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01343/full

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