Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking: report of a case
Abstract An 80-year-old man presented to our emergency department complaining of a mass on the right side of his chest and pain in the right flank of his back. A chest computed tomography (CT) scan showed a relatively heterogenous oval-shaped tumor measuring 7.5 × 6.0 cm eroded to the 8th rib, with...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-02-01
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| Series: | Surgical Case Reports |
| Online Access: | https://doi.org/10.1186/s40792-023-01606-x |
| _version_ | 1797863744857964544 |
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| author | Yuki Itagaki Akira Fukunaga Hironobu Takano Kazuyuki Yamamoto Kohei Nishigami Tatsunosuke Ichimura Hiroto Manase Masahiko Obata Tatsuya Kato Satoshi Hirano |
| author_facet | Yuki Itagaki Akira Fukunaga Hironobu Takano Kazuyuki Yamamoto Kohei Nishigami Tatsunosuke Ichimura Hiroto Manase Masahiko Obata Tatsuya Kato Satoshi Hirano |
| author_sort | Yuki Itagaki |
| collection | DOAJ |
| description | Abstract An 80-year-old man presented to our emergency department complaining of a mass on the right side of his chest and pain in the right flank of his back. A chest computed tomography (CT) scan showed a relatively heterogenous oval-shaped tumor measuring 7.5 × 6.0 cm eroded to the 8th rib, with slightly dense fluid accumulation inside and calcification of the tumor wall. A 1-month follow-up CT scan showed spontaneous shrinkage of the tumor. The tumor was completely excised from the thoracic wall and the wall was reconstructed with a polytetrafluoroethylene mesh. Pathological examination showed coagulation necrosis in the chest wall tumor, but immunohistochemical staining revealed murine double minute 2- and Cyclin-dependent kinase 4-positive cells with irregular nuclear size and bizarre morphology. Therefore, dedifferentiated liposarcoma (DDLPS) was the final pathological diagnosis. Remarkable infiltration of CD8+ lymphocytes into the tumor was observed, along with a 90% positive ratio for programmed cell death-ligand 1. The patient has been followed-up for 1 year without any recurrence, despite not receiving any additional treatment. Liposarcoma is one of the most common types of soft tissue sarcomas; however, spontaneous regression of primary DDLPS arising from the chest wall is extremely rare. Herein, we report a case of DDLPS primary to the chest wall with spontaneous regression, probably due to a spontaneously induced T cell response. |
| first_indexed | 2024-04-09T22:40:32Z |
| format | Article |
| id | doaj.art-700e8d8f9d8b4cbdb0d26f2068f4c01f |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-04-09T22:40:32Z |
| publishDate | 2023-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-700e8d8f9d8b4cbdb0d26f2068f4c01f2023-03-22T12:13:04ZengSpringerOpenSurgical Case Reports2198-77932023-02-01911410.1186/s40792-023-01606-xDedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking: report of a caseYuki Itagaki0Akira Fukunaga1Hironobu Takano2Kazuyuki Yamamoto3Kohei Nishigami4Tatsunosuke Ichimura5Hiroto Manase6Masahiko Obata7Tatsuya Kato8Satoshi Hirano9Department of Surgery, Japanese Red Cross Asahikawa HospitalDepartment of Thoracic Surgery, Japanese Red Cross Asahikawa HospitalDepartment of Surgery, Japanese Red Cross Asahikawa HospitalDepartment of Surgery, Japanese Red Cross Asahikawa HospitalDepartment of Surgery, Japanese Red Cross Asahikawa HospitalDepartment of Surgery, Japanese Red Cross Asahikawa HospitalDepartment of Surgery, Japanese Red Cross Asahikawa HospitalDepartment of Surgical Pathology, Japanese Red Cross Asahikawa HospitalDepartment of Thoracic Surgery, Hokkaido University HospitalDepartment of Gastroenterological Surgery II, Faculty of Medicine, Hokkaido UniversityAbstract An 80-year-old man presented to our emergency department complaining of a mass on the right side of his chest and pain in the right flank of his back. A chest computed tomography (CT) scan showed a relatively heterogenous oval-shaped tumor measuring 7.5 × 6.0 cm eroded to the 8th rib, with slightly dense fluid accumulation inside and calcification of the tumor wall. A 1-month follow-up CT scan showed spontaneous shrinkage of the tumor. The tumor was completely excised from the thoracic wall and the wall was reconstructed with a polytetrafluoroethylene mesh. Pathological examination showed coagulation necrosis in the chest wall tumor, but immunohistochemical staining revealed murine double minute 2- and Cyclin-dependent kinase 4-positive cells with irregular nuclear size and bizarre morphology. Therefore, dedifferentiated liposarcoma (DDLPS) was the final pathological diagnosis. Remarkable infiltration of CD8+ lymphocytes into the tumor was observed, along with a 90% positive ratio for programmed cell death-ligand 1. The patient has been followed-up for 1 year without any recurrence, despite not receiving any additional treatment. Liposarcoma is one of the most common types of soft tissue sarcomas; however, spontaneous regression of primary DDLPS arising from the chest wall is extremely rare. Herein, we report a case of DDLPS primary to the chest wall with spontaneous regression, probably due to a spontaneously induced T cell response.https://doi.org/10.1186/s40792-023-01606-x |
| spellingShingle | Yuki Itagaki Akira Fukunaga Hironobu Takano Kazuyuki Yamamoto Kohei Nishigami Tatsunosuke Ichimura Hiroto Manase Masahiko Obata Tatsuya Kato Satoshi Hirano Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking: report of a case Surgical Case Reports |
| title | Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking: report of a case |
| title_full | Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking: report of a case |
| title_fullStr | Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking: report of a case |
| title_full_unstemmed | Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking: report of a case |
| title_short | Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking: report of a case |
| title_sort | dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking report of a case |
| url | https://doi.org/10.1186/s40792-023-01606-x |
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