Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder
Abstract Patients with Parkinson’s disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, and could predict phenoconversion to neur...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
|
| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-022-00356-1 |
| _version_ | 1797642229392605184 |
|---|---|
| author | Li Zhou Steven W. H. Chau Yaping Liu Jing Wang Jihui Zhang Ngan Yin Chan Joey W. Y. Chan Bei Huang Sijing Chen Shirley Xin Li Vincent Chung Tong Mok Yun Kwok Wing |
| author_facet | Li Zhou Steven W. H. Chau Yaping Liu Jing Wang Jihui Zhang Ngan Yin Chan Joey W. Y. Chan Bei Huang Sijing Chen Shirley Xin Li Vincent Chung Tong Mok Yun Kwok Wing |
| author_sort | Li Zhou |
| collection | DOAJ |
| description | Abstract Patients with Parkinson’s disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, and could predict phenoconversion to neurodegenerative disorders. We aimed to investigate the personality profile and its association with future neurodegenerative phenoconversion in iRBD patients. One hundred and eighty-five video-polysomnography confirmed iRBD patients and 91 age- and sex-matched controls underwent personality assessment using the NEO five-factor inventory, and 171 iRBD patients were followed up. Our results showed that iRBD was marginally negatively associated with extraverted personality trait (B = −0.28, 95% confidence interval (CI) = −0.55, −0.001). During a median follow-up of 5.9 years, 47 iRBD patients (27.5%) had phenoconversion. More neurotic (adjusted hazard ratio (HR) = 2.0, 95% CI = 1.3, 3.1) and less extraverted personality traits (adjusted HR = 0.53, 95% CI = 0.36, 0.77) were associated with an increased risk of phenoconversion in iRBD patients. Our findings suggest that personality profile may be a potential prodromal marker of iRBD. |
| first_indexed | 2024-03-11T13:57:12Z |
| format | Article |
| id | doaj.art-70107db265bb454fb4fa516f7ac6f9fa |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-11T13:57:12Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-70107db265bb454fb4fa516f7ac6f9fa2023-11-02T06:19:27ZengNature Portfolionpj Parkinson's Disease2373-80572022-07-01811710.1038/s41531-022-00356-1Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorderLi Zhou0Steven W. H. Chau1Yaping Liu2Jing Wang3Jihui Zhang4Ngan Yin Chan5Joey W. Y. Chan6Bei Huang7Sijing Chen8Shirley Xin Li9Vincent Chung Tong Mok10Yun Kwok Wing11Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongDepartment of Psychology, The University of Hong KongDepartment of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong KongDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong KongAbstract Patients with Parkinson’s disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, and could predict phenoconversion to neurodegenerative disorders. We aimed to investigate the personality profile and its association with future neurodegenerative phenoconversion in iRBD patients. One hundred and eighty-five video-polysomnography confirmed iRBD patients and 91 age- and sex-matched controls underwent personality assessment using the NEO five-factor inventory, and 171 iRBD patients were followed up. Our results showed that iRBD was marginally negatively associated with extraverted personality trait (B = −0.28, 95% confidence interval (CI) = −0.55, −0.001). During a median follow-up of 5.9 years, 47 iRBD patients (27.5%) had phenoconversion. More neurotic (adjusted hazard ratio (HR) = 2.0, 95% CI = 1.3, 3.1) and less extraverted personality traits (adjusted HR = 0.53, 95% CI = 0.36, 0.77) were associated with an increased risk of phenoconversion in iRBD patients. Our findings suggest that personality profile may be a potential prodromal marker of iRBD.https://doi.org/10.1038/s41531-022-00356-1 |
| spellingShingle | Li Zhou Steven W. H. Chau Yaping Liu Jing Wang Jihui Zhang Ngan Yin Chan Joey W. Y. Chan Bei Huang Sijing Chen Shirley Xin Li Vincent Chung Tong Mok Yun Kwok Wing Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder npj Parkinson's Disease |
| title | Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder |
| title_full | Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder |
| title_fullStr | Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder |
| title_full_unstemmed | Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder |
| title_short | Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder |
| title_sort | personality profile and its association with conversion to neurodegenerative disorders in idiopathic rem sleep behavior disorder |
| url | https://doi.org/10.1038/s41531-022-00356-1 |
| work_keys_str_mv | AT lizhou personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT stevenwhchau personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT yapingliu personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT jingwang personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT jihuizhang personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT nganyinchan personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT joeywychan personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT beihuang personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT sijingchen personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT shirleyxinli personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT vincentchungtongmok personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder AT yunkwokwing personalityprofileanditsassociationwithconversiontoneurodegenerativedisordersinidiopathicremsleepbehaviordisorder |