Venomic, Transcriptomic, and Bioactivity Analyses of <em>Pamphobeteus verdolaga</em> Venom Reveal Complex Disulfide-Rich Peptides That Modulate Calcium Channels

Venomic, Transcriptomic, and Bioactivity Analyses of <em>Pamphobeteus verdolaga</em> Venom Reveal Complex Disulfide-Rich Peptides That Modulate Calcium Channels

<i>Pamphobeteus verdolaga</i> is a recently described Theraphosidae spider from the Andean region of Colombia. Previous reports partially characterized its venom profile. In this study, we conducted a detailed analysis that includes reversed-phase high-performance liquid chromatography (...

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Bibliographic Details
Main Authors: Sebastian Estrada-Gomez, Fernanda Caldas Cardoso, Leidy Johana Vargas-Muñoz, Juan Carlos Quintana-Castillo, Claudia Marcela Arenas Gómez, Sandy Steffany Pineda, Monica Maria Saldarriaga-Cordoba
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Toxins
Subjects:
theraphosidae
<i>Pamphobeteus</i>
peptides
disulfide-rich peptide (DRP)
inhibitory cysteine knot (ICK)
venomics
transcriptome
ion channels
Online Access:https://www.mdpi.com/2072-6651/11/9/496

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