Fish-on-a-chip: a sensitive detection microfluidic system for alzheimer's disease
<p>Abstract</p> <p>Microfluidics has become an important tool in diagnosing many diseases, including neurological and genetic disorders. Alzheimer's disease (AD) is a neurodegenerative disease that irreversibly and progressively destroys memory, language ability, and thinking...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-05-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | http://www.jbiomedsci.com/content/18/1/33 |
| _version_ | 1811250913756577792 |
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| author | An Jeongho Kim Sanghyo Devadhasan Jasmine P |
| author_facet | An Jeongho Kim Sanghyo Devadhasan Jasmine P |
| author_sort | An Jeongho |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Microfluidics has become an important tool in diagnosing many diseases, including neurological and genetic disorders. Alzheimer's disease (AD) is a neurodegenerative disease that irreversibly and progressively destroys memory, language ability, and thinking skills. Commonly, detection of AD is expensive and complex. Fluorescence in situ hybridization (FISH)-based microfluidic chip platform is capable of diagnosing AD at an early stage and they are effective tools for the diagnosis with low cost, high speed, and high sensitivity. In this review, we tried to provide basic information on the diagnosis of AD via FISH-based microfluidics. Different sample preparations using a microfluidic chip for diagnosis of AD are highlighted. Moreover, rapid innovations in nanotechnology for diagnosis are explained. This review will provide information on dynamic quantification methods for the diagnosis and treatment of AD. The knowledge provided in this review will help develop new integration diagnostic techniques based on FISH and microfluidics.</p> |
| first_indexed | 2024-04-12T16:11:53Z |
| format | Article |
| id | doaj.art-70125a0eee1047b6be0a6dfe7f0c9979 |
| institution | Directory Open Access Journal |
| issn | 1021-7770 1423-0127 |
| language | English |
| last_indexed | 2024-04-12T16:11:53Z |
| publishDate | 2011-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-70125a0eee1047b6be0a6dfe7f0c99792022-12-22T03:25:52ZengBMCJournal of Biomedical Science1021-77701423-01272011-05-011813310.1186/1423-0127-18-33Fish-on-a-chip: a sensitive detection microfluidic system for alzheimer's diseaseAn JeonghoKim SanghyoDevadhasan Jasmine P<p>Abstract</p> <p>Microfluidics has become an important tool in diagnosing many diseases, including neurological and genetic disorders. Alzheimer's disease (AD) is a neurodegenerative disease that irreversibly and progressively destroys memory, language ability, and thinking skills. Commonly, detection of AD is expensive and complex. Fluorescence in situ hybridization (FISH)-based microfluidic chip platform is capable of diagnosing AD at an early stage and they are effective tools for the diagnosis with low cost, high speed, and high sensitivity. In this review, we tried to provide basic information on the diagnosis of AD via FISH-based microfluidics. Different sample preparations using a microfluidic chip for diagnosis of AD are highlighted. Moreover, rapid innovations in nanotechnology for diagnosis are explained. This review will provide information on dynamic quantification methods for the diagnosis and treatment of AD. The knowledge provided in this review will help develop new integration diagnostic techniques based on FISH and microfluidics.</p>http://www.jbiomedsci.com/content/18/1/33Fluorescence <it>in situ </it>hybridization (FISH)Microfluidic chipAlzheimer's disease (AD)NanoparticlesMolecular probes |
| spellingShingle | An Jeongho Kim Sanghyo Devadhasan Jasmine P Fish-on-a-chip: a sensitive detection microfluidic system for alzheimer's disease Journal of Biomedical Science Fluorescence <it>in situ </it>hybridization (FISH) Microfluidic chip Alzheimer's disease (AD) Nanoparticles Molecular probes |
| title | Fish-on-a-chip: a sensitive detection microfluidic system for alzheimer's disease |
| title_full | Fish-on-a-chip: a sensitive detection microfluidic system for alzheimer's disease |
| title_fullStr | Fish-on-a-chip: a sensitive detection microfluidic system for alzheimer's disease |
| title_full_unstemmed | Fish-on-a-chip: a sensitive detection microfluidic system for alzheimer's disease |
| title_short | Fish-on-a-chip: a sensitive detection microfluidic system for alzheimer's disease |
| title_sort | fish on a chip a sensitive detection microfluidic system for alzheimer s disease |
| topic | Fluorescence <it>in situ </it>hybridization (FISH) Microfluidic chip Alzheimer's disease (AD) Nanoparticles Molecular probes |
| url | http://www.jbiomedsci.com/content/18/1/33 |
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