Regulation of Angiogenesis by Non-Coding RNAs in Cancer
Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, have been identified as crucial regulators of various biological processes through epigenetic regulation, transcriptional regulation, and post-transcriptional regulation. Growing evidence suggests that dysregulation and a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/1/60 |
| _version_ | 1797344553055813632 |
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| author | Zhiyue Su Wenshu Li Zhe Lei Lin Hu Shengjie Wang Lingchuan Guo |
| author_facet | Zhiyue Su Wenshu Li Zhe Lei Lin Hu Shengjie Wang Lingchuan Guo |
| author_sort | Zhiyue Su |
| collection | DOAJ |
| description | Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, have been identified as crucial regulators of various biological processes through epigenetic regulation, transcriptional regulation, and post-transcriptional regulation. Growing evidence suggests that dysregulation and activation of non-coding RNAs are closely associated with tumor angiogenesis, a process essential for tumor growth and metastasis and a major contributor to cancer-related mortality. Therefore, understanding the molecular mechanisms underlying tumor angiogenesis is of utmost importance. Numerous studies have documented the involvement of different types of non-coding RNAs in the regulation of angiogenesis. This review provides an overview of how non-coding RNAs regulate tumor angiogenesis. Additionally, we discuss emerging strategies that exploit non-coding RNAs for anti-angiogenic therapy in cancer treatment. Ultimately, this review underscores the crucial role played by non-coding RNAs in tumor angiogenesis and highlights their potential as therapeutic targets for anti-angiogenic interventions against cancer. |
| first_indexed | 2024-03-08T11:04:24Z |
| format | Article |
| id | doaj.art-7013c64234554f1483e33ed60a146f31 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-08T11:04:24Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-7013c64234554f1483e33ed60a146f312024-01-26T15:19:02ZengMDPI AGBiomolecules2218-273X2024-01-011416010.3390/biom14010060Regulation of Angiogenesis by Non-Coding RNAs in CancerZhiyue Su0Wenshu Li1Zhe Lei2Lin Hu3Shengjie Wang4Lingchuan Guo5Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, ChinaDepartment of Basic Medicine, Kangda College, Nanjing Medical University, Lianyungang 222000, ChinaDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaNon-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, have been identified as crucial regulators of various biological processes through epigenetic regulation, transcriptional regulation, and post-transcriptional regulation. Growing evidence suggests that dysregulation and activation of non-coding RNAs are closely associated with tumor angiogenesis, a process essential for tumor growth and metastasis and a major contributor to cancer-related mortality. Therefore, understanding the molecular mechanisms underlying tumor angiogenesis is of utmost importance. Numerous studies have documented the involvement of different types of non-coding RNAs in the regulation of angiogenesis. This review provides an overview of how non-coding RNAs regulate tumor angiogenesis. Additionally, we discuss emerging strategies that exploit non-coding RNAs for anti-angiogenic therapy in cancer treatment. Ultimately, this review underscores the crucial role played by non-coding RNAs in tumor angiogenesis and highlights their potential as therapeutic targets for anti-angiogenic interventions against cancer.https://www.mdpi.com/2218-273X/14/1/60miRNAlncRNAcircRNAtumor angiogenesis |
| spellingShingle | Zhiyue Su Wenshu Li Zhe Lei Lin Hu Shengjie Wang Lingchuan Guo Regulation of Angiogenesis by Non-Coding RNAs in Cancer Biomolecules miRNA lncRNA circRNA tumor angiogenesis |
| title | Regulation of Angiogenesis by Non-Coding RNAs in Cancer |
| title_full | Regulation of Angiogenesis by Non-Coding RNAs in Cancer |
| title_fullStr | Regulation of Angiogenesis by Non-Coding RNAs in Cancer |
| title_full_unstemmed | Regulation of Angiogenesis by Non-Coding RNAs in Cancer |
| title_short | Regulation of Angiogenesis by Non-Coding RNAs in Cancer |
| title_sort | regulation of angiogenesis by non coding rnas in cancer |
| topic | miRNA lncRNA circRNA tumor angiogenesis |
| url | https://www.mdpi.com/2218-273X/14/1/60 |
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