Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia
Abstract Background Neonatal hypoglycemia is tightly related to adverse neurodevelopmental and brain injury outcomes. Methods A total of 195 infants who were born from diabetic mothers with a low blood glucose level (< 2.6 mM) within 0.5 h after birth were enrolled in this prospective cohort stud...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | BMC Pediatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s12887-019-1509-4 |
| _version_ | 1818760013410205696 |
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| author | Lin-Xia Qiao Jian Wang Ju-Hua Yan Su-Xiang Xu Hua Wang Wen-Ying Zhu Hai-Yan Zhang Jie Li Xing Feng |
| author_facet | Lin-Xia Qiao Jian Wang Ju-Hua Yan Su-Xiang Xu Hua Wang Wen-Ying Zhu Hai-Yan Zhang Jie Li Xing Feng |
| author_sort | Lin-Xia Qiao |
| collection | DOAJ |
| description | Abstract Background Neonatal hypoglycemia is tightly related to adverse neurodevelopmental and brain injury outcomes. Methods A total of 195 infants who were born from diabetic mothers with a low blood glucose level (< 2.6 mM) within 0.5 h after birth were enrolled in this prospective cohort study. Of these, 157 infants who had neonatal hypoglycemia (group A) were followed up, and this group was further divided into A1 [blood glucose concentration (BGC) < 2.6 mM at < 2 h after birth], A2 (BGC < 2.6 mM at 2–24 h after birth), and A3 (BGC < 2.6 mM at > 24 h after birth). A total of 144 infants whose mothers had no high risk for gestational diabetes mellitus were followed up as the control group during the same period. The neurodevelopment of the infants was evaluated by the Gesell scoring method. Results The adaptability in the A2 and A3 subgroups was significantly lower than that in the control group (73.9 ± 6.6 vs. 87.9 ± 11.2; 71.5 ± 8.9 vs. 87.9 ± 11.2, respectively). There were significantly more mothers who used insulin during the perinatal period in A3 than in A1 and A2 (31% vs. 2%; 31% vs. 7.9%, respectively). The mothers of babies in subgroups A2 and A3 gained more weight than those of the control group (15.3 ± 1.9 kg vs. 11.1 ± 2.2 kg; 14.8 ± 2.6 kg vs. 11.1 ± 2.2 kg, respectively). Conclusions Long and repeated neonatal hypoglycemia caused poor adaptability. The babies of mothers who used insulin or had a high weight gain during pregnancy were associated with severe or persistent neonatal hypoglycemia. |
| first_indexed | 2024-12-18T06:51:52Z |
| format | Article |
| id | doaj.art-7016872e0a8e428187fd2cae969bd102 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-18T06:51:52Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-7016872e0a8e428187fd2cae969bd1022022-12-21T21:17:18ZengBMCBMC Pediatrics1471-24312019-04-011911610.1186/s12887-019-1509-4Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemiaLin-Xia Qiao0Jian Wang1Ju-Hua Yan2Su-Xiang Xu3Hua Wang4Wen-Ying Zhu5Hai-Yan Zhang6Jie Li7Xing Feng8Department of Neonatology, Children’s Hospital of Soochow UniversityDepartment of Children’s Healthcare, Kunshan Maternal and Child Health HospitalDepartment of Children’s Healthcare, Kunshan Maternal and Child Health HospitalDepartment of Children’s Healthcare, Kunshan Maternal and Child Health HospitalDepartment of Pediatrics, The First People’s Hospital, Jiangsu UniversityDepartment of Pediatrics, The First People’s Hospital, Jiangsu UniversityDepartment of Pediatrics, The First People’s Hospital, Jiangsu UniversityDepartment of Pediatrics, The First People’s Hospital, Jiangsu UniversityDepartment of Neonatology, Children’s Hospital of Soochow UniversityAbstract Background Neonatal hypoglycemia is tightly related to adverse neurodevelopmental and brain injury outcomes. Methods A total of 195 infants who were born from diabetic mothers with a low blood glucose level (< 2.6 mM) within 0.5 h after birth were enrolled in this prospective cohort study. Of these, 157 infants who had neonatal hypoglycemia (group A) were followed up, and this group was further divided into A1 [blood glucose concentration (BGC) < 2.6 mM at < 2 h after birth], A2 (BGC < 2.6 mM at 2–24 h after birth), and A3 (BGC < 2.6 mM at > 24 h after birth). A total of 144 infants whose mothers had no high risk for gestational diabetes mellitus were followed up as the control group during the same period. The neurodevelopment of the infants was evaluated by the Gesell scoring method. Results The adaptability in the A2 and A3 subgroups was significantly lower than that in the control group (73.9 ± 6.6 vs. 87.9 ± 11.2; 71.5 ± 8.9 vs. 87.9 ± 11.2, respectively). There were significantly more mothers who used insulin during the perinatal period in A3 than in A1 and A2 (31% vs. 2%; 31% vs. 7.9%, respectively). The mothers of babies in subgroups A2 and A3 gained more weight than those of the control group (15.3 ± 1.9 kg vs. 11.1 ± 2.2 kg; 14.8 ± 2.6 kg vs. 11.1 ± 2.2 kg, respectively). Conclusions Long and repeated neonatal hypoglycemia caused poor adaptability. The babies of mothers who used insulin or had a high weight gain during pregnancy were associated with severe or persistent neonatal hypoglycemia.http://link.springer.com/article/10.1186/s12887-019-1509-4NeonateHypoglycemiaNeurodevelopmentFollow-up |
| spellingShingle | Lin-Xia Qiao Jian Wang Ju-Hua Yan Su-Xiang Xu Hua Wang Wen-Ying Zhu Hai-Yan Zhang Jie Li Xing Feng Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia BMC Pediatrics Neonate Hypoglycemia Neurodevelopment Follow-up |
| title | Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia |
| title_full | Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia |
| title_fullStr | Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia |
| title_full_unstemmed | Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia |
| title_short | Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia |
| title_sort | follow up study of neurodevelopment in 2 year old infants who had suffered from neonatal hypoglycemia |
| topic | Neonate Hypoglycemia Neurodevelopment Follow-up |
| url | http://link.springer.com/article/10.1186/s12887-019-1509-4 |
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