Properties of Adenovirus Vectors with Increased Affinity to DSG2 and the Potential Benefits of Oncolytic Approaches and Gene Therapy

Properties of Adenovirus Vectors with Increased Affinity to DSG2 and the Potential Benefits of Oncolytic Approaches and Gene Therapy

Carcinomas are characterized by a widespread upregulation of intercellular junctions that create a barrier to immune response and drug therapy. Desmoglein 2 (DSG2) represents such a junction protein and serves as one adenovirus receptor. Importantly, the interaction between human adenovirus type 3 (...

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Bibliographic Details
Main Authors: Nora A. Bahlmann, Raphael L. Tsoukas, Sebastian Erkens, Hongjie Wang, Franziska Jönsson, Malik Aydin, Ella A. Naumova, André Lieber, Anja Ehrhardt, Wenli Zhang
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Viruses
Subjects:
adenovirus
carcinomas
CD46-detargeting
desmoglein 2
junction opener 4
receptor
Online Access:https://www.mdpi.com/1999-4915/14/8/1835

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