The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ’s Neurogenic Response after Neonatal Hypoxia-Ischemia
Neonatal hypoxia-ischemia (HI) often causes hypoxic-ischemic encephalopathy (HIE), a neurological condition that can lead to overall disability in newborns. The only treatment available for affected neonates is therapeutic hypothermia; however, cooling is not always effective to prevent the deleteri...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/6/1667 |
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| author | Gorane Beldarrain Enrique Hilario Idoia Lara-Celador Marc Chillida Ana Catalan Antonia Ángeles Álvarez-Diaz Daniel Alonso-Alconada |
| author_facet | Gorane Beldarrain Enrique Hilario Idoia Lara-Celador Marc Chillida Ana Catalan Antonia Ángeles Álvarez-Diaz Daniel Alonso-Alconada |
| author_sort | Gorane Beldarrain |
| collection | DOAJ |
| description | Neonatal hypoxia-ischemia (HI) often causes hypoxic-ischemic encephalopathy (HIE), a neurological condition that can lead to overall disability in newborns. The only treatment available for affected neonates is therapeutic hypothermia; however, cooling is not always effective to prevent the deleterious effects of HI, so compounds such as cannabinoids are currently under research as new therapies. Modulating the endocannabinoid system (ECS) may reduce brain damage and/or stimulate cell proliferation at the neurogenic niches. Further, the long-term effects of cannabinoid treatment are not so clear. Here, we studied the middle- and long-term effects of 2-AG, the most abundant endocannabinoid in the perinatal period after HI in neonatal rats. At middle-term (postnatal day 14), 2-AG reduced brain injury and increased SGZ’s cell proliferation and the number of neuroblasts. At post-natal day 90, the treatment with the endocannabinoid showed global and local protection, suggesting long-lasting neuroprotective effects of 2-AG after neonatal HI in rats. |
| first_indexed | 2024-03-11T02:03:13Z |
| format | Article |
| id | doaj.art-7018710e6fc94674879098809312205e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T02:03:13Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7018710e6fc94674879098809312205e2023-11-18T12:04:46ZengMDPI AGPharmaceutics1999-49232023-06-01156166710.3390/pharmaceutics15061667The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ’s Neurogenic Response after Neonatal Hypoxia-IschemiaGorane Beldarrain0Enrique Hilario1Idoia Lara-Celador2Marc Chillida3Ana Catalan4Antonia Ángeles Álvarez-Diaz5Daniel Alonso-Alconada6Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainPsychiatry Department, OSI Bilbao-Basurto, Basurto University Hospital, 48013 Bilbao, SpainDepartment of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainNeonatal hypoxia-ischemia (HI) often causes hypoxic-ischemic encephalopathy (HIE), a neurological condition that can lead to overall disability in newborns. The only treatment available for affected neonates is therapeutic hypothermia; however, cooling is not always effective to prevent the deleterious effects of HI, so compounds such as cannabinoids are currently under research as new therapies. Modulating the endocannabinoid system (ECS) may reduce brain damage and/or stimulate cell proliferation at the neurogenic niches. Further, the long-term effects of cannabinoid treatment are not so clear. Here, we studied the middle- and long-term effects of 2-AG, the most abundant endocannabinoid in the perinatal period after HI in neonatal rats. At middle-term (postnatal day 14), 2-AG reduced brain injury and increased SGZ’s cell proliferation and the number of neuroblasts. At post-natal day 90, the treatment with the endocannabinoid showed global and local protection, suggesting long-lasting neuroprotective effects of 2-AG after neonatal HI in rats.https://www.mdpi.com/1999-4923/15/6/1667neonatal hypoxia-ischemiaendocannabinoid system2-AGneuroprotectionneurogenesis |
| spellingShingle | Gorane Beldarrain Enrique Hilario Idoia Lara-Celador Marc Chillida Ana Catalan Antonia Ángeles Álvarez-Diaz Daniel Alonso-Alconada The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ’s Neurogenic Response after Neonatal Hypoxia-Ischemia Pharmaceutics neonatal hypoxia-ischemia endocannabinoid system 2-AG neuroprotection neurogenesis |
| title | The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ’s Neurogenic Response after Neonatal Hypoxia-Ischemia |
| title_full | The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ’s Neurogenic Response after Neonatal Hypoxia-Ischemia |
| title_fullStr | The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ’s Neurogenic Response after Neonatal Hypoxia-Ischemia |
| title_full_unstemmed | The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ’s Neurogenic Response after Neonatal Hypoxia-Ischemia |
| title_short | The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ’s Neurogenic Response after Neonatal Hypoxia-Ischemia |
| title_sort | long term neuroprotective effect of the endocannabinoid 2 ag and modulation of the sgz s neurogenic response after neonatal hypoxia ischemia |
| topic | neonatal hypoxia-ischemia endocannabinoid system 2-AG neuroprotection neurogenesis |
| url | https://www.mdpi.com/1999-4923/15/6/1667 |
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