A T > G Mutation in the NR5A2 Gene Is Associated With Litter Size in Hu Sheep Through Upregulation of Promoter Activity by Transcription Factor MTF-1

A T > G Mutation in the NR5A2 Gene Is Associated With Litter Size in Hu Sheep Through Upregulation of Promoter Activity by Transcription Factor MTF-1

Nuclear receptor subfamily 5 group A member 2 (NR5A2), also referred to as LRH-1 or FTF, is an orphan nuclear hormone receptor that is involved in regulating embryonic development, ovarian granulosa cell differentiation, gonadal sex differentiation, and steroidogenesis in mammals. However, little is...

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Bibliographic Details
Main Authors: Yinxia Li, Jun Zhang, Yong Qian, Chunhua Meng, Huili Wang, Jifeng Zhong, Shaoxian Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Genetics
Subjects:
Hu sheep
NR5A2
core promoter
single nucleotide polymorphism
competitive EMSA
MTF-1
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01011/full

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