The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm
There is evidence that diet and nutrition are modifiable risk factors for several cancers. In recent years, attention paid to micronutrients in gynecology has increased, especially regarding Human papillomavirus (HPV) infection. We performed a review of the literature up until December 2022, aiming...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/11/1652 |
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| author | Filippo Alberto Ferrari Francesca Magni Mariachiara Bosco Giulia Biancotto Pier Carlo Zorzato Antonio Simone Laganà Vito Chiantera Ricciarda Raffaelli Massimo Franchi Stefano Uccella Simone Garzon |
| author_facet | Filippo Alberto Ferrari Francesca Magni Mariachiara Bosco Giulia Biancotto Pier Carlo Zorzato Antonio Simone Laganà Vito Chiantera Ricciarda Raffaelli Massimo Franchi Stefano Uccella Simone Garzon |
| author_sort | Filippo Alberto Ferrari |
| collection | DOAJ |
| description | There is evidence that diet and nutrition are modifiable risk factors for several cancers. In recent years, attention paid to micronutrients in gynecology has increased, especially regarding Human papillomavirus (HPV) infection. We performed a review of the literature up until December 2022, aiming to clarify the effects of micronutrients, minerals, and vitamins on the history of HPV infection and the development of cervical cancer. We included studies having as their primary objective the evaluation of dietary supplements, in particular calcium; zinc; iron; selenium; carotenoids; and vitamins A, B12, C, D, E, and K. Different oligo-elements and micronutrients demonstrated a potential protective role against cervical cancer by intervening in different stages of the natural history of HPV infection, development of cervical dysplasia, and invasive disease. Healthcare providers should be aware of and incorporate the literature evidence in counseling, although the low quality of evidence provided by available studies recommends further well-designed investigations to give clear indications for clinical practice. |
| first_indexed | 2024-03-11T03:06:37Z |
| format | Article |
| id | doaj.art-7018b5fd817f4bcb8c517e4a094cddf0 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T03:06:37Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-7018b5fd817f4bcb8c517e4a094cddf02023-11-18T07:54:24ZengMDPI AGHealthcare2227-90322023-06-011111165210.3390/healthcare11111652The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and NeoplasmFilippo Alberto Ferrari0Francesca Magni1Mariachiara Bosco2Giulia Biancotto3Pier Carlo Zorzato4Antonio Simone Laganà5Vito Chiantera6Ricciarda Raffaelli7Massimo Franchi8Stefano Uccella9Simone Garzon10Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyDepartment of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyDepartment of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyDepartment of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyDepartment of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyUnit of Gynecologic Oncology, ARNAS “Civico-Di Cristina-Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, ItalyUnit of Gynecologic Oncology, ARNAS “Civico-Di Cristina-Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, ItalyDepartment of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyDepartment of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyDepartment of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyDepartment of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyThere is evidence that diet and nutrition are modifiable risk factors for several cancers. In recent years, attention paid to micronutrients in gynecology has increased, especially regarding Human papillomavirus (HPV) infection. We performed a review of the literature up until December 2022, aiming to clarify the effects of micronutrients, minerals, and vitamins on the history of HPV infection and the development of cervical cancer. We included studies having as their primary objective the evaluation of dietary supplements, in particular calcium; zinc; iron; selenium; carotenoids; and vitamins A, B12, C, D, E, and K. Different oligo-elements and micronutrients demonstrated a potential protective role against cervical cancer by intervening in different stages of the natural history of HPV infection, development of cervical dysplasia, and invasive disease. Healthcare providers should be aware of and incorporate the literature evidence in counseling, although the low quality of evidence provided by available studies recommends further well-designed investigations to give clear indications for clinical practice.https://www.mdpi.com/2227-9032/11/11/1652human papillomaviruscervical dysplasiacervical cancermicronutrientscancer prevention |
| spellingShingle | Filippo Alberto Ferrari Francesca Magni Mariachiara Bosco Giulia Biancotto Pier Carlo Zorzato Antonio Simone Laganà Vito Chiantera Ricciarda Raffaelli Massimo Franchi Stefano Uccella Simone Garzon The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm Healthcare human papillomavirus cervical dysplasia cervical cancer micronutrients cancer prevention |
| title | The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm |
| title_full | The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm |
| title_fullStr | The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm |
| title_full_unstemmed | The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm |
| title_short | The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm |
| title_sort | role of micronutrients in human papillomavirus infection cervical dysplasia and neoplasm |
| topic | human papillomavirus cervical dysplasia cervical cancer micronutrients cancer prevention |
| url | https://www.mdpi.com/2227-9032/11/11/1652 |
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