Immunological considerations of modern animal models of malignant primary brain tumors
<p>Abstract</p> <p>Recent advances in animal models of glioma have facilitated a better understanding of biological mechanisms underlying gliomagenesis and glioma progression. The limitations of existing therapy, including surgery, chemotherapy, and radiotherapy, have prompted nume...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-10-01
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| Series: | Journal of Translational Medicine |
| Online Access: | http://www.translational-medicine.com/content/7/1/84 |
| _version_ | 1818790998079176704 |
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| author | James C David Fang Shanna Rutkowski Martin J Kane Ari J Yang Isaac Sughrue Michael E Parsa Andrew T |
| author_facet | James C David Fang Shanna Rutkowski Martin J Kane Ari J Yang Isaac Sughrue Michael E Parsa Andrew T |
| author_sort | James C David |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Recent advances in animal models of glioma have facilitated a better understanding of biological mechanisms underlying gliomagenesis and glioma progression. The limitations of existing therapy, including surgery, chemotherapy, and radiotherapy, have prompted numerous investigators to search for new therapeutic approaches to improve quantity and quality of survival from these aggressive lesions. One of these approaches involves triggering a tumor specific immune response. However, a difficulty in this approach is the the scarcity of animal models of primary CNS neoplasms which faithfully recapitulate these tumors and their interaction with the host's immune system. In this article, we review the existing methods utilized to date for modeling gliomas in rodents, with a focus on the known as well as potential immunological aspects of these models. As this review demonstrates, many of these models have inherent immune system limitations, and the impact of these limitations on studies on the influence of pre-clinical therapeutics testing warrants further attention.</p> |
| first_indexed | 2024-12-18T15:04:21Z |
| format | Article |
| id | doaj.art-70194d2285da44b786f8bf0441569520 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-18T15:04:21Z |
| publishDate | 2009-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-70194d2285da44b786f8bf04415695202022-12-21T21:03:49ZengBMCJournal of Translational Medicine1479-58762009-10-01718410.1186/1479-5876-7-84Immunological considerations of modern animal models of malignant primary brain tumorsJames C DavidFang ShannaRutkowski Martin JKane Ari JYang IsaacSughrue Michael EParsa Andrew T<p>Abstract</p> <p>Recent advances in animal models of glioma have facilitated a better understanding of biological mechanisms underlying gliomagenesis and glioma progression. The limitations of existing therapy, including surgery, chemotherapy, and radiotherapy, have prompted numerous investigators to search for new therapeutic approaches to improve quantity and quality of survival from these aggressive lesions. One of these approaches involves triggering a tumor specific immune response. However, a difficulty in this approach is the the scarcity of animal models of primary CNS neoplasms which faithfully recapitulate these tumors and their interaction with the host's immune system. In this article, we review the existing methods utilized to date for modeling gliomas in rodents, with a focus on the known as well as potential immunological aspects of these models. As this review demonstrates, many of these models have inherent immune system limitations, and the impact of these limitations on studies on the influence of pre-clinical therapeutics testing warrants further attention.</p>http://www.translational-medicine.com/content/7/1/84 |
| spellingShingle | James C David Fang Shanna Rutkowski Martin J Kane Ari J Yang Isaac Sughrue Michael E Parsa Andrew T Immunological considerations of modern animal models of malignant primary brain tumors Journal of Translational Medicine |
| title | Immunological considerations of modern animal models of malignant primary brain tumors |
| title_full | Immunological considerations of modern animal models of malignant primary brain tumors |
| title_fullStr | Immunological considerations of modern animal models of malignant primary brain tumors |
| title_full_unstemmed | Immunological considerations of modern animal models of malignant primary brain tumors |
| title_short | Immunological considerations of modern animal models of malignant primary brain tumors |
| title_sort | immunological considerations of modern animal models of malignant primary brain tumors |
| url | http://www.translational-medicine.com/content/7/1/84 |
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