Sacubitril/valsartan inhibits the proliferation of vascular smooth muscle cells through notch signaling and ERK1/2 pathway

Sacubitril/valsartan inhibits the proliferation of vascular smooth muscle cells through notch signaling and ERK1/2 pathway

Abstract Aims To explore the role and mechanism of Notch signaling and ERK1/2 pathway in the inhibitory effect of sacubitril/valsartan on the proliferation of vascular smooth muscle cells (VSMCs). Main methods Human aortic vascular smooth muscle cells (HA-VSMCs) were cultured in vitro. The prolifera...

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Bibliographic Details
Main Authors: Congfeng Xu, Ning Zhang, Hong Yuan, Liren Wang, Yonghong Li
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Cardiovascular Disorders
Subjects:
Restenosis
Vascular smooth muscle cells
Sacubitril/valsartan
Notch1
Jagged1
ERK1/2
Online Access:https://doi.org/10.1186/s12872-024-03764-8

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