Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel Film
Indwelling urethral catheters are widely used in hospitalized patients. However, they are associated with bacterial infection and biofilm formation due to the suboptimal surface properties of the elastic materials used for the catheters. Although there are several antibacterial coating technologies...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Materials |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmats.2019.00274/full |
| _version_ | 1819149200092299264 |
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| author | Kisuk Yang Kisuk Yang Kisuk Yang Kisuk Yang Kyuri Kim Eunjee A. Lee Eunjee A. Lee Sophie S. Liu Sara Kabli Sara Kabli Samar A. Alsudir Samar A. Alsudir Shahad Albrahim Angela Zhou Tae Gwan Park Haeshin Lee Abdulaziz M. Almalik Abdulaziz M. Almalik Jeffrey M. Karp Jeffrey M. Karp Jeffrey M. Karp Jeffrey M. Karp Ali H. Alhasan Ali H. Alhasan Ali H. Alhasan Yuhan Lee Yuhan Lee Yuhan Lee |
| author_facet | Kisuk Yang Kisuk Yang Kisuk Yang Kisuk Yang Kyuri Kim Eunjee A. Lee Eunjee A. Lee Sophie S. Liu Sara Kabli Sara Kabli Samar A. Alsudir Samar A. Alsudir Shahad Albrahim Angela Zhou Tae Gwan Park Haeshin Lee Abdulaziz M. Almalik Abdulaziz M. Almalik Jeffrey M. Karp Jeffrey M. Karp Jeffrey M. Karp Jeffrey M. Karp Ali H. Alhasan Ali H. Alhasan Ali H. Alhasan Yuhan Lee Yuhan Lee Yuhan Lee |
| author_sort | Kisuk Yang |
| collection | DOAJ |
| description | Indwelling urethral catheters are widely used in hospitalized patients. However, they are associated with bacterial infection and biofilm formation due to the suboptimal surface properties of the elastic materials used for the catheters. Although there are several antibacterial coating technologies to modify the surface properties of the catheter including hydrophilic polymeric coating, the risk of infection is still high given the absence of reactive functional groups on the surface of elastomers. In this study, we describe the use of catechol-functionalized hydrophilic polymers and explore strategies to create antibacterial hydrogel coatings. Three different types of catechol-functionalized polymers, chitosan, hyaluronic acid, and human serum albumin were synthesized and deposited using simple dip-coating method. All of the tested polymers could coat different types of elastomers widely used for urethral catheters independent of the surface properties while the thickness of the coating could be controlled by the number of depositions. The coating formed stable water-containing lubricant surface beneficial as a physical repellant of microbial attachment. In addition, the coating could be combined with additional antibacterial agents such as silver nanoparticles to maximize the antibacterial effect on the surface of urethral catheter materials. |
| first_indexed | 2024-12-22T13:57:49Z |
| format | Article |
| id | doaj.art-701b3a1057174ac5bd5414d7b07b06cd |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-12-22T13:57:49Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-701b3a1057174ac5bd5414d7b07b06cd2022-12-21T18:23:31ZengFrontiers Media S.A.Frontiers in Materials2296-80162019-12-01610.3389/fmats.2019.00274479773Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel FilmKisuk Yang0Kisuk Yang1Kisuk Yang2Kisuk Yang3Kyuri Kim4Eunjee A. Lee5Eunjee A. Lee6Sophie S. Liu7Sara Kabli8Sara Kabli9Samar A. Alsudir10Samar A. Alsudir11Shahad Albrahim12Angela Zhou13Tae Gwan Park14Haeshin Lee15Abdulaziz M. Almalik16Abdulaziz M. Almalik17Jeffrey M. Karp18Jeffrey M. Karp19Jeffrey M. Karp20Jeffrey M. Karp21Ali H. Alhasan22Ali H. Alhasan23Ali H. Alhasan24Yuhan Lee25Yuhan Lee26Yuhan Lee27Engineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesHarvard-MIT Division of Health Sciences & Technology, Cambridge, MA, United StatesKACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaProteomics Platform, Broad Institute of Harvard and MIT, Cambridge, MA, United StatesDepartment of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaEngineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesHarvard-MIT Division of Health Sciences & Technology, Cambridge, MA, United StatesEngineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesKACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaNational Center for Pharmaceutical Technology, Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaKACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaNational Center for Pharmaceutical Technology, Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaKACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaEngineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaDepartment of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaKACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaNational Center for Pharmaceutical Technology, Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaEngineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesHarvard-MIT Division of Health Sciences & Technology, Cambridge, MA, United StatesKACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaProteomics Platform, Broad Institute of Harvard and MIT, Cambridge, MA, United StatesKACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaNational Center for Pharmaceutical Technology, Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaCollege of Science and General Studies, Alfaisal University, Riyadh, Saudi ArabiaEngineering in Medicine, Department of Medicine, Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesHarvard-MIT Division of Health Sciences & Technology, Cambridge, MA, United StatesKACST-BWH Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaIndwelling urethral catheters are widely used in hospitalized patients. However, they are associated with bacterial infection and biofilm formation due to the suboptimal surface properties of the elastic materials used for the catheters. Although there are several antibacterial coating technologies to modify the surface properties of the catheter including hydrophilic polymeric coating, the risk of infection is still high given the absence of reactive functional groups on the surface of elastomers. In this study, we describe the use of catechol-functionalized hydrophilic polymers and explore strategies to create antibacterial hydrogel coatings. Three different types of catechol-functionalized polymers, chitosan, hyaluronic acid, and human serum albumin were synthesized and deposited using simple dip-coating method. All of the tested polymers could coat different types of elastomers widely used for urethral catheters independent of the surface properties while the thickness of the coating could be controlled by the number of depositions. The coating formed stable water-containing lubricant surface beneficial as a physical repellant of microbial attachment. In addition, the coating could be combined with additional antibacterial agents such as silver nanoparticles to maximize the antibacterial effect on the surface of urethral catheter materials.https://www.frontiersin.org/article/10.3389/fmats.2019.00274/fullurethral cathetersurface coatingcatecholhydrogellubricityanti-bacterial adhesion |
| spellingShingle | Kisuk Yang Kisuk Yang Kisuk Yang Kisuk Yang Kyuri Kim Eunjee A. Lee Eunjee A. Lee Sophie S. Liu Sara Kabli Sara Kabli Samar A. Alsudir Samar A. Alsudir Shahad Albrahim Angela Zhou Tae Gwan Park Haeshin Lee Abdulaziz M. Almalik Abdulaziz M. Almalik Jeffrey M. Karp Jeffrey M. Karp Jeffrey M. Karp Jeffrey M. Karp Ali H. Alhasan Ali H. Alhasan Ali H. Alhasan Yuhan Lee Yuhan Lee Yuhan Lee Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel Film Frontiers in Materials urethral catheter surface coating catechol hydrogel lubricity anti-bacterial adhesion |
| title | Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel Film |
| title_full | Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel Film |
| title_fullStr | Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel Film |
| title_full_unstemmed | Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel Film |
| title_short | Robust Low Friction Antibiotic Coating of Urethral Catheters Using a Catechol-Functionalized Polymeric Hydrogel Film |
| title_sort | robust low friction antibiotic coating of urethral catheters using a catechol functionalized polymeric hydrogel film |
| topic | urethral catheter surface coating catechol hydrogel lubricity anti-bacterial adhesion |
| url | https://www.frontiersin.org/article/10.3389/fmats.2019.00274/full |
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