Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis
Here, we report on a rare case of gastric hyperplastic polyps which disappeared after the discontinuation of proton pump inhibitor (PPI). The patient was an 83-year-old woman with liver cirrhosis and portal hypertension, along with gastroesophageal reflux disease treated by PPI. An initial upper gas...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-02-01
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| Series: | Case Reports in Gastroenterology |
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| Online Access: | https://www.karger.com/Article/FullText/511885 |
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| author | Kengo Yasugi Ken Haruma Miwa Kawanaka Mitsuhiko Suehiro Jun Nakamura Noriyo Urata Tomohiro Tanikawa Takahito Oka Yasumasa Monobe Takuya Fujita Hirofumi Kawamoto |
| author_facet | Kengo Yasugi Ken Haruma Miwa Kawanaka Mitsuhiko Suehiro Jun Nakamura Noriyo Urata Tomohiro Tanikawa Takahito Oka Yasumasa Monobe Takuya Fujita Hirofumi Kawamoto |
| author_sort | Kengo Yasugi |
| collection | DOAJ |
| description | Here, we report on a rare case of gastric hyperplastic polyps which disappeared after the discontinuation of proton pump inhibitor (PPI). The patient was an 83-year-old woman with liver cirrhosis and portal hypertension, along with gastroesophageal reflux disease treated by PPI. An initial upper gastrointestinal endoscopy showed unique polypoid lesions in the greater curvature of the stomach. Biopsy specimens of the lesions were diagnosed as hyperplastic polyps and she was followed. One year later, a second endoscopy showed that the lesions had increased in number and size, and an endoscopic mucosal resection (EMR) was performed for the main polyps. The resected specimens indicated a proliferation of foveolar epithelium cells with an increase of capillary ectasia and parietal cell hyperplasia, which was thought to be induced by hypergastrinemia from the PPI. Three months after the EMR, she was admitted because of bleeding from the remaining polyps along with an increase in new polyps. After conservative treatment, PPI was stopped and rebamipide was used. One year and 6 months later, an endoscopy showed the complete disappearance of all gastric polyps. |
| first_indexed | 2024-12-13T23:39:56Z |
| format | Article |
| id | doaj.art-701b8e8572a3477e801905048544f1cd |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-13T23:39:56Z |
| publishDate | 2021-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-701b8e8572a3477e801905048544f1cd2022-12-21T23:27:12ZengKarger PublishersCase Reports in Gastroenterology1662-06312021-02-0115120220910.1159/000511885511885Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver CirrhosisKengo YasugiKen HarumaMiwa KawanakaMitsuhiko SuehiroJun NakamuraNoriyo UrataTomohiro TanikawaTakahito OkaYasumasa MonobeTakuya FujitaHirofumi KawamotoHere, we report on a rare case of gastric hyperplastic polyps which disappeared after the discontinuation of proton pump inhibitor (PPI). The patient was an 83-year-old woman with liver cirrhosis and portal hypertension, along with gastroesophageal reflux disease treated by PPI. An initial upper gastrointestinal endoscopy showed unique polypoid lesions in the greater curvature of the stomach. Biopsy specimens of the lesions were diagnosed as hyperplastic polyps and she was followed. One year later, a second endoscopy showed that the lesions had increased in number and size, and an endoscopic mucosal resection (EMR) was performed for the main polyps. The resected specimens indicated a proliferation of foveolar epithelium cells with an increase of capillary ectasia and parietal cell hyperplasia, which was thought to be induced by hypergastrinemia from the PPI. Three months after the EMR, she was admitted because of bleeding from the remaining polyps along with an increase in new polyps. After conservative treatment, PPI was stopped and rebamipide was used. One year and 6 months later, an endoscopy showed the complete disappearance of all gastric polyps.https://www.karger.com/Article/FullText/511885gastric hyperplastic polypproton pump inhibitorhypergastrinemia |
| spellingShingle | Kengo Yasugi Ken Haruma Miwa Kawanaka Mitsuhiko Suehiro Jun Nakamura Noriyo Urata Tomohiro Tanikawa Takahito Oka Yasumasa Monobe Takuya Fujita Hirofumi Kawamoto Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis Case Reports in Gastroenterology gastric hyperplastic polyp proton pump inhibitor hypergastrinemia |
| title | Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis |
| title_full | Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis |
| title_fullStr | Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis |
| title_full_unstemmed | Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis |
| title_short | Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis |
| title_sort | disappearance of gastric hyperplastic polyps after the discontinuation of proton pump inhibitor in a patient with liver cirrhosis |
| topic | gastric hyperplastic polyp proton pump inhibitor hypergastrinemia |
| url | https://www.karger.com/Article/FullText/511885 |
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