The Interaction Efficiency of XPD-p44 With Bulky DNA Damages Depends on the Structure of the Damage

The Interaction Efficiency of XPD-p44 With Bulky DNA Damages Depends on the Structure of the Damage

The successful elimination of bulky DNA damages via the nucleotide excision repair (NER) system is largely determined by the damage recognition step. This step consists of primary recognition and verification of the damage. The TFIIH helicase XPD plays a key role in the verification step during NER....

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Bibliographic Details
Main Authors: Irina Petruseva, Natalia Naumenko, Jochen Kuper, Rashid Anarbaev, Jeannette Kappenberger, Caroline Kisker, Olga Lavrik
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
nucleotide excision repair
XPD helicase
DNA damage
protein-DNA interaction
bulky damages recognition
photo-cross-linking
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.617160/full

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