Hepatocytes: A key role in liver inflammation
Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular functions including carbohydrate, lipid and protein metabolism, detoxification and immune cell activation to maintain liver homeotasis. Recent studies show hepatocytes play a pivotal role in liver inflam...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1083780/full |
| _version_ | 1797950519534157824 |
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| author | Jin Gong Wei Tu Jingmei Liu Dean Tian |
| author_facet | Jin Gong Wei Tu Jingmei Liu Dean Tian |
| author_sort | Jin Gong |
| collection | DOAJ |
| description | Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular functions including carbohydrate, lipid and protein metabolism, detoxification and immune cell activation to maintain liver homeotasis. Recent studies show hepatocytes play a pivotal role in liver inflammation. After receiving liver insults and inflammatory signals, hepatocytes may undergo organelle damage, and further respond by releasing mediators and expressing molecules that can act in the microenvironment as well as initiate a robust inflammatory response. In this review, we summarize how the hepatic organelle damage link to liver inflammation and introduce numerous hepatocyte-derived pro-inflammatory factors in response to chronic liver injury. |
| first_indexed | 2024-04-10T22:16:25Z |
| format | Article |
| id | doaj.art-701bebd97a8e491397477c9e8f318cd2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T22:16:25Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-701bebd97a8e491397477c9e8f318cd22023-01-18T07:49:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011310.3389/fimmu.2022.10837801083780Hepatocytes: A key role in liver inflammationJin GongWei TuJingmei LiuDean TianHepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular functions including carbohydrate, lipid and protein metabolism, detoxification and immune cell activation to maintain liver homeotasis. Recent studies show hepatocytes play a pivotal role in liver inflammation. After receiving liver insults and inflammatory signals, hepatocytes may undergo organelle damage, and further respond by releasing mediators and expressing molecules that can act in the microenvironment as well as initiate a robust inflammatory response. In this review, we summarize how the hepatic organelle damage link to liver inflammation and introduce numerous hepatocyte-derived pro-inflammatory factors in response to chronic liver injury.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1083780/fullhepatocyteorganelle damagehepatic inflammationextracellular vesiclescytokines |
| spellingShingle | Jin Gong Wei Tu Jingmei Liu Dean Tian Hepatocytes: A key role in liver inflammation Frontiers in Immunology hepatocyte organelle damage hepatic inflammation extracellular vesicles cytokines |
| title | Hepatocytes: A key role in liver inflammation |
| title_full | Hepatocytes: A key role in liver inflammation |
| title_fullStr | Hepatocytes: A key role in liver inflammation |
| title_full_unstemmed | Hepatocytes: A key role in liver inflammation |
| title_short | Hepatocytes: A key role in liver inflammation |
| title_sort | hepatocytes a key role in liver inflammation |
| topic | hepatocyte organelle damage hepatic inflammation extracellular vesicles cytokines |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1083780/full |
| work_keys_str_mv | AT jingong hepatocytesakeyroleinliverinflammation AT weitu hepatocytesakeyroleinliverinflammation AT jingmeiliu hepatocytesakeyroleinliverinflammation AT deantian hepatocytesakeyroleinliverinflammation |