Vitamin B12 effectiveness in the management of hospitalized COVID‐19 and its clinical outcomes and complications: A randomized clinical trial
Abstract Background and Aims Since 2019, severe acute respiratory syndrome coronavirus 2, has spread and challenged the health care system for treatment which is mainly limited to supportive care. It is well‐established that malnutrition impedes the immunity in human bodies, and makes it vulnerable...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1509 |
| _version_ | 1827805764464410624 |
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| author | Zahra Erfani Nafiseh Alizadeh Neda Faraji Alireza Teymouri |
| author_facet | Zahra Erfani Nafiseh Alizadeh Neda Faraji Alireza Teymouri |
| author_sort | Zahra Erfani |
| collection | DOAJ |
| description | Abstract Background and Aims Since 2019, severe acute respiratory syndrome coronavirus 2, has spread and challenged the health care system for treatment which is mainly limited to supportive care. It is well‐established that malnutrition impedes the immunity in human bodies, and makes it vulnerable to microorganisms. Vitamin B12 is one of the agents that has critical roles in body systems. Thus, the following clinical trial was conducted to assess its possible therapeutic value in COVID‐19 patients. Method The present randomized clinical trial was carried out in Baharlou Hospital, and patients with confirmed COVID‐19 infection within 24 h of admission were included. We used quadruple blocks randomization to divide patients into groups of case and control. The case group received 1000 mg of vitamin B12, daily for 7 day while the patients in control group were administered distilled water as placebo. The studied outcomes were duration of hospitalization, need for intensive care unit (ICU), mechanical ventilation, mortality rate and laboratory findings. The statistical analysis was done via SPSS version 22. Results After implementing inclusion and exclusion criteria, 34 participants were included in the study, 20 of which were male. Serum levels of creatinine, LDH (Lactate dehydrogenase), Ferritin, and CRP (C‐reactive protein) had decreased in both groups. The improving changes of CRP, LDH, ferritin and creatinine was higher in case group. The increase of Alanine Transaminase and D‐dimer was higher in control group. however there was no statistically significant difference. More patients were admitted to ICU in the control group but the difference was not statistically significant. Duration of hospitalization did not differ statistically between the groups. No in hospital mortality has been recorded. Conclusion Our study suggests that vitamin B12 supplementation seem to have curative effect in COVID‐19. Nutritious diet is necessary for proper functioning of the immune system. Since malnutrition is associated with poor prognosis in COVID‐19 patients, and limited number of participants in this study, we suggest performing meta‐analysis on similar studies to reach reliable result. |
| first_indexed | 2024-03-11T21:30:50Z |
| format | Article |
| id | doaj.art-701cd06113f4416695f855321ac052cf |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-11T21:30:50Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-701cd06113f4416695f855321ac052cf2023-09-27T09:16:35ZengWileyHealth Science Reports2398-88352023-09-0169n/an/a10.1002/hsr2.1509Vitamin B12 effectiveness in the management of hospitalized COVID‐19 and its clinical outcomes and complications: A randomized clinical trialZahra Erfani0Nafiseh Alizadeh1Neda Faraji2Alireza Teymouri3School of Medicine Tehran University of Medical Sciences Tehran IranBaharlou Hospital Research Center Tehran University of Medical Sciences Tehran IranSchool of Medicine Tehran University of Medical Sciences Tehran IranSchool of Medicine Tehran University of Medical Sciences Tehran IranAbstract Background and Aims Since 2019, severe acute respiratory syndrome coronavirus 2, has spread and challenged the health care system for treatment which is mainly limited to supportive care. It is well‐established that malnutrition impedes the immunity in human bodies, and makes it vulnerable to microorganisms. Vitamin B12 is one of the agents that has critical roles in body systems. Thus, the following clinical trial was conducted to assess its possible therapeutic value in COVID‐19 patients. Method The present randomized clinical trial was carried out in Baharlou Hospital, and patients with confirmed COVID‐19 infection within 24 h of admission were included. We used quadruple blocks randomization to divide patients into groups of case and control. The case group received 1000 mg of vitamin B12, daily for 7 day while the patients in control group were administered distilled water as placebo. The studied outcomes were duration of hospitalization, need for intensive care unit (ICU), mechanical ventilation, mortality rate and laboratory findings. The statistical analysis was done via SPSS version 22. Results After implementing inclusion and exclusion criteria, 34 participants were included in the study, 20 of which were male. Serum levels of creatinine, LDH (Lactate dehydrogenase), Ferritin, and CRP (C‐reactive protein) had decreased in both groups. The improving changes of CRP, LDH, ferritin and creatinine was higher in case group. The increase of Alanine Transaminase and D‐dimer was higher in control group. however there was no statistically significant difference. More patients were admitted to ICU in the control group but the difference was not statistically significant. Duration of hospitalization did not differ statistically between the groups. No in hospital mortality has been recorded. Conclusion Our study suggests that vitamin B12 supplementation seem to have curative effect in COVID‐19. Nutritious diet is necessary for proper functioning of the immune system. Since malnutrition is associated with poor prognosis in COVID‐19 patients, and limited number of participants in this study, we suggest performing meta‐analysis on similar studies to reach reliable result.https://doi.org/10.1002/hsr2.1509B12CovidCovid‐19vitamin B12 |
| spellingShingle | Zahra Erfani Nafiseh Alizadeh Neda Faraji Alireza Teymouri Vitamin B12 effectiveness in the management of hospitalized COVID‐19 and its clinical outcomes and complications: A randomized clinical trial Health Science Reports B12 Covid Covid‐19 vitamin B12 |
| title | Vitamin B12 effectiveness in the management of hospitalized COVID‐19 and its clinical outcomes and complications: A randomized clinical trial |
| title_full | Vitamin B12 effectiveness in the management of hospitalized COVID‐19 and its clinical outcomes and complications: A randomized clinical trial |
| title_fullStr | Vitamin B12 effectiveness in the management of hospitalized COVID‐19 and its clinical outcomes and complications: A randomized clinical trial |
| title_full_unstemmed | Vitamin B12 effectiveness in the management of hospitalized COVID‐19 and its clinical outcomes and complications: A randomized clinical trial |
| title_short | Vitamin B12 effectiveness in the management of hospitalized COVID‐19 and its clinical outcomes and complications: A randomized clinical trial |
| title_sort | vitamin b12 effectiveness in the management of hospitalized covid 19 and its clinical outcomes and complications a randomized clinical trial |
| topic | B12 Covid Covid‐19 vitamin B12 |
| url | https://doi.org/10.1002/hsr2.1509 |
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